329-StaVia: Temporal Spatially Aware Cell Atlas Cartography
The article introduces StaVia, a novel computational framework designed for single-cell atlases, which are large datasets detailing cellular states and differentiation. StaVia addresses major challenges in trajectory inference by integrating spatial and temporal metadata with a method utilizing higher-order random walks with memory to accurately trace complex cell lineage pathways. The framework also includes a cartographic Atlas View for intuitive visualization of these large-scale trajectories, outperforming existing methods like UMAP and CellRank in maintaining both global continuity and…
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