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1010-Spatial Atlas of Diabetic Kidney Disease

Scientists have developed a comprehensive spatial atlas of the human kidney to better understand the cellular architecture of diabetic kidney disease (DKD). By integrating high-resolution single-cell transcriptomics with existing genomic data, researchers identified specific tissue niches and microenvironments that change as the disease advances. A significant discovery was a unique B cell-rich immune environment that specifically indicates a higher risk for rapid kidney failure. This research produced new biomarkers and plasma protein panels capable of predicting patient outcomes more…

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