162-T Cell Phenotype and Clonality in Human Tumors
This paper details a multimodal profiling framework developed to study T cell function in head and neck squamous cell carcinoma (HNSCC), a cancer that often resists immune checkpoint blockade. This research integrates single-cell RNA- and TCR-sequencing with spatial transcriptomics, including a novel method for spatially-resolved TCR profiling at single-cell resolution. The primary finding is that T cell function and phenotype are not solely determined by clonal identity or antigen specificity, but are dynamically shaped by their spatial location and microenvironmental cues within the tumor…
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