Pharma 22: Local Anaesthetics - Silencing Pain at the Source

Clinical Deep Dives · Feb 2, 2026 · 1m

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This episode focuses on local anaesthetics as tools of precision. Rather than altering awareness, these agents selectively block pain transmission by stabilising excitable membranes at the site of action. We explore how sodium channel blockade translates into predictable sensory loss, why different fibres fall silent at different rates, and how anatomy,…