1112-Gut Microbiota & Cancer Immunotherapy
Recent research has established that the gut microbiota and its associated metabolic products are fundamental regulators of immune checkpoint blockade (ICB) efficacy in cancer treatment. These microorganisms influence therapeutic outcomes through various mechanisms, including antigenic cross-reactivity, the movement of microbes to lymph nodes, and the systemic circulation of metabolites like short-chain fatty acids. Furthermore, dietary habits significantly dictate these interactions, as high-fiber intake generally bolsters anti-tumor immunity while high-fat diets can lead to more varied or…
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