1246-Reversible mTOR Mechanisms in Alzheimer’s Disease
This research investigates the molecular drivers of axonal spheroids, which are swollen nerve fiber structures that cluster around amyloid plaques and disrupt brain connectivity in Alzheimer’s disease. By utilizing advanced proximity labeling proteomics on human and mouse brain tissues, the authors identified hundreds of proteins involved in lipid transport, cytoskeletal dynamics, and protein turnover. A key discovery is the overactivation of the PI3K/AKT/mTOR signaling pathway within these spheroids, which appears to fuel their pathological growth. Using human iPSC-derived neurons and animal…
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