1640-Plasticity of Myeloid Cells in Aging and Alzheimer’s
This study introduces a high-resolution cellular atlas of the human brain's immune system, specifically focusing on the microglia and macrophages within the prefrontal cortex. By analyzing over 800,000 cells from more than 1,600 donors, researchers established a reproducible taxonomy consisting of 13 distinct functional subtypes. A primary discovery is the GPNMB subtype, an Alzheimer’s-associated microglial state that expands as the disease progresses and is regulated by the transcription factor MITF. The authors utilized causal mediation analysis to demonstrate that this specific cellular…
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