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Alzheimer's Origin Discovered in Brain Cells | New York City News

Columbia researchers are zeroing in on the very first spark of Alzheimer’s—tiny brain structures called endosomes that malfunction early, causing cellular traffic jams. Using Grand Central Station as an analogy, they’re mapping how these breakdowns disrupt thinking and feeling. Led by Dr. Scott Small, the team is developing drugs to fix these glitches, still in early stages. Dr. Yasir Qureshi’s work with mice and human tissue shows promise: reversing damage in animals could pave the way for real treatments. This breakthrough could change everything for millions—though it’ll still take years…

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