575-Brain-Wide Atlas of Oligodendrocyte and Myelin Dynamics
This research introduces a sophisticated brain-wide mapping pipeline designed to analyze oligodendrocyte organization and myelin health across varying ages and disease states. By utilizing lightsheet microscopy and deep learning algorithms, the authors generated high-resolution atlases that reveal how myelin patterns are established and maintained throughout a mouse's lifespan. The study identifies specific regional vulnerabilities, noting that while some brain areas are resilient to injury, others, like the hippocampus, exhibit significant cell loss during demyelination. Integration with…
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