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GPH 10: Genomics and Public Health · Clinical Deep Dives

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  SPEAKER_00: This is the Brief on Genomics and Public Health.
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  SPEAKER_00: We're looking at how genomic science is leaping from studying rare,
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  SPEAKER_00: isolated mutations into a massive,
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  data-driven engine meant to prevent everyday diseases for the
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  entire global
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  SPEAKER_00: population.
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  SPEAKER_00: First, we're experiencing a shift from rare to everywhere.
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  Genomics used to just mean screening newborns for rare,
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  single-gene disorders like PKU.
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  SPEAKER_00: Now,
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  SPEAKER_00: it's about common,
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  complex diseases and how our genes interact with our
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  environment across our
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  SPEAKER_00: lifespan.
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  It's kind of like moving from fixing a single leaky pipe to
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  completely upgrading a
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  SPEAKER_00: whole city's plumbing system.
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  SPEAKER_00: Second,
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  SPEAKER_00: expanding that focus requires better testing,
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  SPEAKER_00: meaning a flood of predictive genetic tests hitting the market.
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  These tests absolutely must pass strict criteria,
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  like analytical validity – is it accurate?
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  SPEAKER_00: And clinical validity – does it predict the disease?
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  SPEAKER_00: But wait,
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  SPEAKER_00: if a test spots a random gene variant,
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  SPEAKER_00: does it actually give us a game plan to improve our health,
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  SPEAKER_00: or does it just give us pointless anxiety?
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  SPEAKER_00: That's why clinical utility is the ultimate hardest hurdle to clear.
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  SPEAKER_00: Finally, clearing that hurdle relies heavily on big data.
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  SPEAKER_00: Science is leaning on massive initiatives like the ENCODE project,
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  SPEAKER_00: which assigned functions to over 80% of the human genome.
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  I mean,
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  we're talking about handling petabytes of data here,
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  which is just mind-blowing.
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  SPEAKER_00: This massive scale birth vaccinomics.
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  SPEAKER_00: So instead of trial and error,
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  we're precision designing vaccines based on the unique genomic
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  profiles of both the
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  SPEAKER_00: host and the pathogen to custom build immunity.
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  SPEAKER_00: Ultimately, genomics is no longer just about knowing your family tree.
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  It's a precision-engineered,
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  big data tool completely transforming the future of global
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  health.