Flipping the Switch to Reduce Addiction Risk in Opioid Painkillers

Recovery News | Mental Health & Addiction Recovery · Oct 19, 2026 · 2m

Opioid medications like morphine and oxycodone remain among the most potent clinical tools for managing severe acute and chronic pain. However, their widespread medical use is fraught with risk, as these drugs trigger intense dopamine release in the brain's reward pathways alongside pain suppression—frequently leading to tolerance, physical dependence, and addiction. For decades, scientists debated whether pain relief and addictive euphoria could ever be separated at the cellular level. According to a landmark biomedical report published by Penn Today, neuroscientists at the University of…