Thiamin and Folic Acid for Cognitive Impairment in Hemodialysis Patients

Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology · May 2, 2026 · 13m

This clinical trial investigated the efficacy and safety of a combined vitamin B treatment for patients with cognitive impairment undergoing maintenance hemodialysis. Researchers conducted a prospective, double-blind study where 215 participants received either a daily dose of thiamin and folic acid or a placebo for nearly two years. The results showed that the treatment group experienced significant cognitive improvement across multiple domains, including memory and executive function, alongside a notable reduction in homocysteine levels. Furthermore, while mortality rates remained…