324-Sympathetic Stress Links Hair Loss to Autoimmunity
The paper describes a two-part physiological and immunological mechanism by which acute stress damages hair follicles and triggers autoimmunity. Initially, acute stress causes the sympathetic nervous system to become hyperactivated, releasing excessive norepinephrine which induces a calcium surge that leads to necrosis—or uncontrolled death—of the highly proliferative hair follicle cells (HF-TACs). This immediate necrotic event is highly inflammatory, prompting antigen-presenting cells to capture the resulting cellular debris. Subsequently, this process leads to the activation and expansion…
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