1406-The PLAU-ITGB1-TGF-β Axis in OSCC Immunosuppression
The study investigates the molecular mechanisms driving oral squamous cell carcinoma (OSCC) progression through an integrated multi-omics approach. Researchers identified a specific subpopulation of COL11A1+ fibroblasts that localize at the tumor’s invasive front to create an immunosuppressive microenvironment. The study reveals that malignant epithelial cells secrete PLAU, which activates the TGF-β pathway via the ITGB1 receptor on fibroblasts to trigger this cellular reprogramming. This signaling axis leads to extracellular matrix remodeling and the recruitment of regulatory T cells…
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