1649-Clinicogenomic Evolution in Colorectal Cancer
This research presents an integrated clinicogenomic analysis of more than 7,000 colorectal cancer (CRC) cases, linking genetic evolution to patient outcomes. The study highlights how recurrent oncogenic mutations are often clonal and further amplified by allelic imbalance, which intensifies their biological impact. By tracking these changes, the authors identified distinct metastatic patterns, noting that certain pathways, like RAS, increase the risk of spread to all organs. Conversely, the WNT pathway appears to offer some protection against extensive metastasis. These findings culminated in…
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