Episode 55: What is the Difference Between Retatrutide and Tirzepatide?

The Peptide Research Podcast · May 4, 2026 · 7m · transcript

Episode 55

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Tirzepatide works as a dual agonist, targeting GLP-1 and GIP to help regulate appetite, digestion, and insulin response. Retatrutide builds on that by adding a third pathway, the glucagon receptor, which may play a role in increasing energy expenditure and influencing fat metabolism.

Researchers…