1476-ILC2 Regulates Pancreatic Fibroblast Progenitor Niches
This research article identifies Group 2 innate lymphoid cells (ILC2s) as essential architects of the pancreatic fibroblast landscape, maintaining organ health and responding to injury. The study reveals that ILC2s reside in a specific interstitial niche where they communicate with Pi16+Dpp4+Ly6c+ fibroblasts, a unique subset with progenitor capabilities. When activated by the alarmin IL-33, ILC2s release IL-13 to stimulate the proliferation of these precursors, which subsequently differentiate into mature fibroblasts to repair tissue. The researchers also discovered that this immune-stromal…
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