1485-Zonated Mechanosensing Controls Liver Regeneration
The research article identifies a specialized population of DPP4+ hepatocytes located in the liver's mid-lobular zone 2 that serves as a primary engine for organ regeneration. These cells act as a mechanical hotspot, using the mechanosensitive ion channel PIEZO1 to detect physical changes like cellular hypertrophy and tissue tension following injury. Once activated by these mechanical cues, PIEZO1 triggers a signaling pathway involving calcium influx and the transcription factor NFATC3 to increase IGFBP2 expression. This process effectively translates physical stress into a proliferative…
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