Lyme and Alzheimer’s: A Hidden Trigger Behind the Markers?

Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf · Nov 4, 2026 · 1h 27m

While amyloid and p-tau are widely viewed as the culprits behind Alzheimer's, they are fundamentally antimicrobial peptides that the brain generates to protect itself. On Peptides and Longevity, Dr. Richard Horowitz explains why that moves the question to what they are responding to. He walks through the case report he published this year, in which a patient with 15 years of chronic Lyme symptoms saw an elevated p-tau217 return to the normal range after a nine-week dapsone combination protocol. We also go through his 16-point MSIDS map to track down the root of chronic inflammation.

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