1680-Gut Microbiota Primes Stroke Severity
The paper investigate how gut microbiota and tryptophan metabolism influence ischemic stroke severity through aryl hydrocarbon receptor (AHR) signaling in intestinal dendritic cells (DCs). Researchers discovered that indole-producing Escherichia coli worsens stroke outcomes by activating AHR in CD11c+ cells, whereas genetic deletion or pharmacological inhibition of AHR preserves conventional type 1 dendritic cells, reduces neuroinflammation, and promotes regulatory T cell (Treg) accumulation. Furthermore, experiments demonstrate that Tregs are essential for the neuroprotective benefits of AHR…
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