726-ChatSpatial: Agentic for Spatial Transcriptomics

Paper Talk · Apr 1, 2026 · 21m

ChatSpatial is a newly developed computational platform designed to streamline spatial transcriptomics analysis by bridging the fragmented software ecosystems of Python and R. By utilizing the Model Context Protocol (MCP), the system implements schema-enforced orchestration, which constrains large language models to pre-validated tool categories rather than allowing them to generate error-prone, free-form code. This architecture unifies over 60 analytical methods, enabling researchers to execute complex tasks like cell communication and copy number inference through simple natural language…