612-A Spatial Atlas of the Mouse Brain Complement System
This research article presents a comprehensive spatial transcriptomic atlas of the complement system within the mouse brain, spanning from embryonic stages to adulthood. Using MERFISH technology, the authors mapped the expression of 51 complement-related genes, discovering that most are produced locally with high cellular and regional diversity. While the classical pathway increases during maturation to facilitate synaptic pruning, the study identifies a previously unknown role for the alternative pathway in early brain development. Specifically, the researchers found that Masp3, an…
The skinny
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