1536-Bacterial STAND Receptors Sense the Core Phage Proteome
Researchers have identified a vast repertoire of prokaryotic STAND NTPases that function as antiviral defense systems by recognizing conserved components of the phage proteome. Through systematic phylogenetic analysis and genetic screening, the study uncovered at least 90 distinct protein families capable of sensing various structural and replicative phage proteins, including the major capsid protein (MCP). A detailed investigation of the Avs7 family revealed that it forms an asymmetric tetrameric complex upon binding to the MCP, a process significantly enhanced by the repurposing of the…
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