Latest / Skin Anarchy / The Science Of Nutrition and Aging Ft. Jan Marini - E.422

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The Science Of Nutrition and Aging Ft. Jan Marini - E.422 · Skin Anarchy

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• 1:29
  SPEAKER_02: Hey guys, welcome back to another episode with the amazing Jan Marini.
• 1:35
  SPEAKER_02: She is truly such an icon, right?
• 1:37
  SPEAKER_02: Well, I'm so excited to dive into this episode with you guys.
• 1:40
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• 1:48
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• 1:53
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• 2:03
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• 2:05
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• 2:13
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• 2:17
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• 2:18
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• 2:21
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• 2:23
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• 2:29
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• 2:35
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• 2:43
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• 2:58
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• 3:01
  SPEAKER_02: You can reach me directly if you'd like.
• 3:03
  SPEAKER_02: Uh, email me at Ecta E K T A, K before the T at Skincare Anarchy Podcast, all one word.com.
• 3:12
  SPEAKER_02: Again, that's ecta at skincareanarchypodcast.com.
• 3:17
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• 3:24
  SPEAKER_02: But I hope you guys reach out and I hope to hear from you.
• 3:26
  SPEAKER_02: And for now, I'm gonna leave you here with Jan and her brilliance because she is truly the queen of skincare, and I am just so honored to have had this opportunity again to host her and to learn from her most importantly.
• 3:39
  SPEAKER_02: Enjoy the show, guys, and thank you again for everything that you do to support us.
• 3:53
  SPEAKER_02: Hi guys, welcome back to Skincare Anarchy.
• 3:56
  SPEAKER_02: This is Ecta, and this is another episode in the Jen Moraney Masterclass series.
• 4:01
  SPEAKER_02: I'm very excited um to have Jen back today.
• 4:04
  SPEAKER_02: Welcome back, Jen.
• 4:05
  SPEAKER_02: I'm so excited.
• 4:06
  SPEAKER_02: Thank you.
• 4:06
  SPEAKER_02: I am happy to be here.
• 4:08
  SPEAKER_02: Happy New Year, everybody.
• 4:09
  SPEAKER_02: Happy New Year, yes, indeed.
• 4:11
  SPEAKER_02: And um, you know, it this one is gonna be really fun because it's about nutrition and how that uh impacts us and our aging process.
• 4:19
  SPEAKER_02: So, Jen, I'm really excited to talk to you about this this topic specifically.
• 4:23
  SPEAKER_04: This is uh an exciting and it's a fun topic.
• 4:28
  SPEAKER_02: Yes, it's really, really fun.
• 4:30
  SPEAKER_02: And I think a lot more information needs to be shared anyway.
• 4:34
  SPEAKER_02: So let's get started.
• 4:36
  SPEAKER_02: Um, I wanted to ask you to open the interview, um, what is the general position today among cutting edge researchers um regarding um, you know, both internally and externally, this topic in general?
• 4:51
  SPEAKER_04: Well, you know, it kind of sounds like science fiction, but the premise is becoming more mainstream.
• 4:56
  SPEAKER_04: And here's the premise we don't have to age.
• 5:01
  SPEAKER_04: Now, that doesn't mean we're not gonna die.
• 5:03
  SPEAKER_04: I'm not talking about living forever, but aging is considered a disease.
• 5:07
  SPEAKER_04: And because we all get older, we all age, um, it's it's looked at as inevitable.
• 5:14
  SPEAKER_04: But when you think about aging, you know, a disease is considered something that affects 50% or less of the population, typically.
• 5:22
  SPEAKER_04: Whether we talk about heart disease, we talk about cancer, we talk about diabetes, etc.
• 5:27
  SPEAKER_04: And aging is really a series of these opportunistic diseases, if you will.
• 5:35
  SPEAKER_04: So it makes sense that in many respects, aging is actually a disease.
• 5:41
  SPEAKER_04: And one of the things I want to say, I am not an expert.
• 5:46
  SPEAKER_04: I don't know if there's any one person today that is an expert on this subject in totality, but it's fun to talk about.
• 5:56
  SPEAKER_04: And I love to put out there the kinds of things that are being discussed and what is cutting edge, but I'm not an expert.
• 6:04
  SPEAKER_04: So that's something you want to talk to your doctor about.
• 6:08
  SPEAKER_02: Yeah, no, I mean, I think that it's it's definitely something that people want to be more educated on too.
• 6:13
  SPEAKER_02: I mean, I know that when you hear the word nutrition, a lot of you listening out there, I'm sure your ears perk up because there is such little information out there, you know, that's really um valid and it's actually applicable to skin health, and especially when it comes to signs of aging, you know, whether that is your skin or not.
• 6:30
  SPEAKER_02: It could be anything.
• 6:31
  SPEAKER_02: So I I agree with you, Jan.
• 6:33
  SPEAKER_02: I think it's a it's an interesting field for sure, you know.
• 6:36
  SPEAKER_02: But I want to I want to know, um, is it something that is in our personal control, you know, or is it something that um we can like kind of deter with drugs, or is there like a miracle drug out there that you've come across, you know?
• 6:50
  SPEAKER_02: What do you think about that?
• 6:52
  SPEAKER_04: Really, um you to completely reverse aging.
• 6:55
  SPEAKER_04: And I'll I'll talk about this a little while later because I had a discussion last week with a professor who's been at Stanford University now for probably 50 years or more, highly respected.
• 7:09
  SPEAKER_04: He and his team developed a molecule that they believe will actually stop aging.
• 7:15
  SPEAKER_04: Um, but so you know, we're probably a long way off.
• 7:18
  SPEAKER_04: And he was telling me that's probably 10 years off because you know, you go through the FDA, etc.
• 7:23
  SPEAKER_04: But there are constant new developments that we're gonna be able to target, and and we're gonna be able to treat and even reverse certain aspects of aging.
• 7:32
  SPEAKER_04: And some, you know, a lot of these things are here today.
• 7:36
  SPEAKER_04: And there are things that we can do as individuals that are within our control.
• 7:41
  SPEAKER_04: You know, when it comes to aging, it's really being referred to today as health span as opposed to life span.
• 7:52
  SPEAKER_04: Um, you know, it's it it's it's for example, it's estimated that the genetics only account for about 20% of our health span.
• 8:05
  SPEAKER_04: That means that we influence at least 80% of our health.
• 8:13
  SPEAKER_04: And this is so important because let's say that you live to be 90 years old.
• 8:18
  SPEAKER_04: Now I'd hopefully I'd like to live to be a lot older than that, but if we you live to be 90, there could be five to eight years of bad health and inactivity where you're incapacitated.
• 8:32
  SPEAKER_04: So when we talk about health span, it's about really being able to have being healthy and being viable and relevant and being able to enjoy life, hopefully right up to the end of our life.
• 8:46
  SPEAKER_04: And this is such an enormous subject, I have to tell you.
• 8:50
  SPEAKER_04: Now, we're we're not even going to be able to scratch the surface today.
• 8:53
  SPEAKER_04: So again, it's not medical advice.
• 8:55
  SPEAKER_04: I'm not a master, but um, we can talk about the overall direction and some really exciting advances.
• 9:04
  SPEAKER_02: Absolutely.
• 9:04
  SPEAKER_02: Yeah, no, I think you made a really great point, you know, in terms of um like what percentage of our lifespan, you know, is in our hands.
• 9:14
  SPEAKER_02: Because I I see I see that a lot, you know, even in patients that I come across is that, you know, it's like a switch that turns on in people where they start realizing I need to take care of myself.
• 9:24
  SPEAKER_02: And when they do that, you just start seeing so many shifts occurring in them.
• 9:30
  SPEAKER_02: And, you know, it I think it is also like a uh mentality as well, you know, it's it's like understanding and coming to peace with the idea that I have to take care of my body, you know, I have to do more things now than I did when I was 20 years old.
• 9:44
  SPEAKER_02: So it's definitely I completely you know understand what you were saying, um, you know, about that aspect.
• 9:48
  SPEAKER_04: It definitely You know, I have to say that hopefully the majority of us are born with good health and we're healthy, certainly as children and young adults, but at some point, you know, and and I and I think that's that's sort of a gift, but at some point it becomes a decision.
• 10:09
  SPEAKER_02: Yeah.
• 10:10
  SPEAKER_02: Yeah, absolutely.
• 10:11
  SPEAKER_02: No, it's it's a huge decision.
• 10:13
  SPEAKER_02: You have to make it proactively.
• 10:15
  SPEAKER_02: You have to know what you're putting in your body, on your body, what you're doing that might be impacting.
• 10:20
  SPEAKER_02: I completely agree.
• 10:21
  SPEAKER_02: So, you know, it I know that you know, we're both like, and and I agree with you, this is not medical advice for everyone listening, but you know, um, when we look at the whole aging process overall, um, could you walk us through um, you know, in your own words, like how do we age?
• 10:38
  SPEAKER_02: What is what is that process?
• 10:40
  SPEAKER_04: I am going to greatly oversimplify it.
• 10:42
  SPEAKER_04: However, I'm gonna, for discussion purposes, I'm gonna break it down into sort of three categories.
• 10:47
  SPEAKER_04: So the first one is inflammation.
• 10:50
  SPEAKER_04: Aging is really considered an inflammatory disease, and in a sense, we're all rusting to death.
• 10:55
  SPEAKER_04: And inflammation contributes to heart disease, arthritis, it's a causative factor in diabetes.
• 11:00
  SPEAKER_04: It causes tissue degeneration, uh, you know, um, it damages our immune system, um, our ability to repair, tissue repair, cancer rates rise.
• 11:12
  SPEAKER_04: And when you look at even aging skin externally, um that's inflammation because most of aging, 90 to 95 percent of what we consider as inevitable aging externally is triggered by UV radiation.
• 11:26
  SPEAKER_04: Acne is an inflammatory disorder, rosaceous inflammatory inflammatory disorder, discoloration is triggered or exacerbated by inflammation from UV radiation.
• 11:36
  SPEAKER_04: Um, the second is compromised instructions from our DNA.
• 11:41
  SPEAKER_04: And um I'll get more into that, but the third one is the gradual shutdown of anti-aging genes called sertuans.
• 11:53
  SPEAKER_04: And there's about 24 of these anti-aging genes.
• 11:58
  SPEAKER_04: Um so why do we stay in an anabolic state for 20 to 25 years?
• 12:05
  SPEAKER_04: We rebuild, we grow, we develop muscle mass, we're energetic, we're healthy, and then we begin to slip into a catabolic state, and we start a gradual decline that decreases over time.
• 12:17
  SPEAKER_04: Well, sertuans play a major role in enabling our body to repair, to rebuild, to remain healthy and vibrant and energetic.
• 12:29
  SPEAKER_04: And sirtuins are made up of proteins.
• 12:33
  SPEAKER_04: Now, I I'm not real good at pronouncing this, but the the proteins are known as nicotinamide, adenine, dinucleotide.
• 12:42
  SPEAKER_04: And that protein is critical for sirtuans to function.
• 12:47
  SPEAKER_04: So think of sirtuans um like a car sitting in your driveway.
• 12:53
  SPEAKER_04: Now, this car is perfect, the engine works, doesn't have any dents or anything like that, but as we age, we don't have enough of these proteins, so the car sits there, it's in perfect condition, but it just doesn't work.
• 13:09
  SPEAKER_04: And so it it needs these proteins to function, and sirtuins play a role in controlling our DNA repair, controlling inflammation, they play a role in health and fitness and survival, our memory, and sertuans help to prevent uh senescent cells from accumulating.
• 13:32
  SPEAKER_04: Now, sensescent cells don't divide, but they don't die.
• 13:36
  SPEAKER_04: So they take up room, but they really don't do anything.
• 13:40
  SPEAKER_04: So, in other words, they prevent other cells that are able to function more fully, that are not compromised, from being able to take that place.
• 13:49
  SPEAKER_04: They're sometimes referred to as zombie cells.
• 13:52
  SPEAKER_04: You want to eliminate them, you don't want these guys sitting there.
• 13:55
  SPEAKER_04: You know, it's like that if you look at a crossword puzzle and you see those black spots, yeah, black squares in the crosswords, that's that's kind of what it they just take up room, but they don't do anything.
• 14:06
  SPEAKER_04: So when you eliminate them, you stimulate new tissue production.
• 14:11
  SPEAKER_04: So um maintaining and turning on Sirtuans will we believe will definitely increase our health span and our longevity.
• 14:22
  SPEAKER_04: Now, one other thing I want to say about sirtuans, and again, I'm gonna I'll get more into this, but one of the only things that has ever been shown to actually increase lifespan, and these are studies that have been done in animal studies, is calorie restriction.
• 14:45
  SPEAKER_04: So if you take in these these studies, if you take and you limit calories and not limit nutrition, so in other words, you're giving really good nutrition, but you're limiting the calories extensively.
• 15:00
  SPEAKER_04: Um they find that in these animal studies they live to be about the equivalent of 150 human years.
• 15:08
  SPEAKER_04: Um and the reason we think that's the case is because doing that turns on sirtuans.
• 15:17
  SPEAKER_04: Now there's a workaround that I'll get to a little bit later.
• 15:22
  SPEAKER_02: Yeah, no, I mean that's really interesting because I've heard of sirtuans and I um, you know, I was actually one of my colleagues was doing research um on this topic, and you know, it really makes sense what you're saying because for everyone listening, just to add to what Jan said, sirtuans are an NAD, um, NAD is a form of energy in your body.
• 15:42
  SPEAKER_02: Okay.
• 15:43
  SPEAKER_02: And so when you have a lot of NAD, that means your body um and your it's specifically in your mitochondria, um, is where the energy cycle happens.
• 15:52
  SPEAKER_02: So there's a thing called the electron transport chain.
• 15:55
  SPEAKER_02: That's where NAD is involved.
• 15:57
  SPEAKER_02: And if you limit um the amount of energy you're putting in your body, which is like through calories, this makes sense.
• 16:05
  SPEAKER_02: You know, it's gonna impact how these specific um proteins are functioning, you know, and and that that makes sense what you said, Jen.
• 16:13
  SPEAKER_02: I just I find it to be so interesting.
• 16:15
  SPEAKER_02: Yeah.
• 16:17
  SPEAKER_02: Um, I wanna actually, uh, you know, just to build off of that, um, what can we really do though, like in terms of addressing, you know, any kind of issues that we do have?
• 16:27
  SPEAKER_02: Um, you know, or really, in other words, like, is there anything we can do to limit or reverse the processes of aging?
• 16:35
  SPEAKER_04: Well, this is where it starts to get really exciting, and it gives us a glimpse of what's coming in the future.
• 16:41
  SPEAKER_04: So here's what we're finding today, and there are four areas that I'm gonna focus on.
• 16:46
  SPEAKER_04: One is diet, one is intermittent fasting, one is supplementation, and the other one is anti-aging drugs.
• 16:58
  SPEAKER_06: Yeah, so anti-aging drugs, that's a good thing.
• 17:03
  SPEAKER_02: Um let's start with diet.
• 17:05
  SPEAKER_02: Yeah, that's a good place to start.
• 17:07
  SPEAKER_02: Let's do diet, yeah.
• 17:08
  SPEAKER_04: Well, again, an oversimplification, but first of all, when we talk about diet, number one, first and foremost, sugar is inflammatory.
• 17:19
  SPEAKER_02: Yeah, yeah.
• 17:20
  SPEAKER_04: And so when you when when you look at the outside, you know, when you look at your skin as it ages, one of the things that sugar does is it attaches to proteins that make up collagen in our dermis.
• 17:31
  SPEAKER_04: You know, 80% of our dermis is is collagen.
• 17:34
  SPEAKER_04: And it causes the collagen to stiffen, to deteriorate, to decrease.
• 17:38
  SPEAKER_04: One study showed that if you eliminate sugar for two weeks, just two weeks, 25% of your bad collagen improves.
• 17:49
  SPEAKER_04: And sugar may be a causative factor in many conditions related to a lot of the things that I pointed out about inflammation.
• 17:58
  SPEAKER_04: Um, you know, do you remember in I think it was uh I think it was the 70s where we were obsessed, we were obsessed with fat.
• 18:08
  SPEAKER_04: Everything had to be non-fat.
• 18:10
  SPEAKER_04: And there was um actually a famous clinic, and I'm trying to think of the name of it, it was in Southern California, and people would go to sometimes for several days or a week or two or three weeks, and literally their diet was absolutely no fat because it was believed that it was going to play a major factor in heart disease and aging and those kinds of things.
• 18:32
  SPEAKER_04: And we found out now that actually fat is good.
• 18:35
  SPEAKER_04: The real culprit in many of these cases is sugar.
• 18:40
  SPEAKER_04: Um and so we know that um most researchers who are looking at longevity, and virtually every single one of them that I've talked to or that I've worked with, and I also have a tremendous amount of respect for David Sinclair, who wrote the book Why We Age and Why We Don't Have To, and that's just a tremendous book, and he is he's he's brilliant.
• 19:05
  SPEAKER_04: But every one of them talk about you need to be on a low carb diet.
• 19:11
  SPEAKER_04: And it's not we're we're not talking about uh the glycemic index per se, we're talking about the glycemic load because so many times when you eat something that you think is actually maybe healthy, um, it turns into more sugar in your body than actually eating sugar.
• 19:32
  SPEAKER_04: And a good example of that that I like to use all the time, I use this example where you have a piece of whole wheat bread and it's a great piece of whole wheat bread, but it will turn into more sugar in your body than taking an entire quarter cup of sugar.
• 19:46
  SPEAKER_06: Yeah.
• 19:47
  SPEAKER_04: And so um so a low-carb diet is really important because it keeps down inflammation.
• 19:54
  SPEAKER_04: And then the other thing that just kind of as an aside is absolutely conclusive.
• 20:02
  SPEAKER_04: We know this beyond a doubt.
• 20:04
  SPEAKER_04: Um, the studies have been published, and that is that milk causes acne.
• 20:09
  SPEAKER_02: Yeah.
• 20:10
  SPEAKER_02: So is that like directly like it causes acne?
• 20:14
  SPEAKER_02: Like, can you elaborate on that?
• 20:18
  SPEAKER_04: So, what it is, it's not that we give hormones to cattle, it's that we milk them when they're pregnant.
• 20:24
  SPEAKER_04: So if a cow's in the wild it and it becomes pregnant, it will push the calf away, it will not allow it to nurse any longer because it's producing steroidal hormones, among other things.
• 20:37
  SPEAKER_04: And so when you when you think about um dairy, and this was a study that was done, by the way, on 47,000 nurses, it was repeated on their sons and daughters, and then there were two separate studies of 3,000 teenage girls and 3,000 teenage boys.
• 20:50
  SPEAKER_04: So it's a causative factor and exacerbates acne.
• 20:53
  SPEAKER_04: And that would be whether it's whole milk, whether it is non-fat milk, and non-fat milk, by the way, is worse because they use whey protein to make the milk look thicker, look make it look more um or more opaque, and the whey protein is more concentrated, so it has more of these factors.
• 21:11
  SPEAKER_04: And so that's ice cream.
• 21:13
  SPEAKER_04: That's all the kinds of things that you know we tend to think um are healthy, and um so it low carb and you know, avoiding those kinds of things.
• 21:26
  SPEAKER_02: Yeah, like dairy, they always say um, you know, dairy really causes breakouts, you know, stay away from dairy.
• 21:33
  SPEAKER_02: And I see a lot of people that just stop eating their yogurt every day.
• 21:36
  SPEAKER_02: And I'm like, you don't you don't need to do that.
• 21:39
  SPEAKER_02: You know, it's it's I think it's really about figuring out what is uh, you know, what part of dairy is is hurting your skin or what you're reacting to.
• 21:47
  SPEAKER_02: Yeah.
• 21:48
  SPEAKER_04: And I think that's a good point because for some people, um, butter isn't a problem, for example.
• 21:53
  SPEAKER_04: Yeah, yeah, exactly.
• 21:55
  SPEAKER_02: No, I know, and I've seen this a lot too.
• 21:57
  SPEAKER_02: I mean, it's not just butter, but it's like you mentioned Ice cream.
• 22:00
  SPEAKER_02: Like some people are, you know, um, like they'll notice that, you know, if they drink milk, it causes them to break out.
• 22:07
  SPEAKER_02: But then they eat ice cream, they're fine.
• 22:09
  SPEAKER_02: You know, they eat butter, they're fine.
• 22:11
  SPEAKER_04: You know, and you have to be careful because a lot of times it also it's a whey protein.
• 22:16
  SPEAKER_04: So if you're drinking a lot of protein drinks that are whey protein as opposed to collagen protein or egg protein or pea protein or something like that, or if you're eating protein bars that are primarily whey protein, that can be a problem.
• 22:32
  SPEAKER_02: Yeah, now those are that's that's a topic that I I think we should like also like talk about more on a whole different episode because that is so important, especially nowadays, because I see so many like, you know, there's such a uh health craze right now, you know, especially on TikTok.
• 22:48
  SPEAKER_02: Um, whenever I go on there, people are like really into this stuff these days, you know, uh incorporating protein into their diet.
• 22:55
  SPEAKER_02: And how many different ways can you have what kind of protein should you use?
• 22:59
  SPEAKER_02: Plant-based, animal-based, you know, all that stuff.
• 23:01
  SPEAKER_02: So and I definitely um understand where you're coming from because there's a significant difference.
• 23:08
  SPEAKER_02: Um, you know, my brother, for example, he had really bad acne.
• 23:11
  SPEAKER_02: And then when he cut out his protein shakes daily, I know that it made a huge difference in his skin, something he didn't even know was happening, you know.
• 23:19
  SPEAKER_02: So that makes sense.
• 23:21
  SPEAKER_04: And they're just there are there are, you know, different egg protein and you know, we don't think about, we just think protein, protein.
• 23:28
  SPEAKER_04: But um, I was just on a website the other day with protein bars where they were using things like pea protein and um other sources of protein besides whey protein.
• 23:38
  SPEAKER_04: So there, you know, there are other options out there.
• 23:41
  SPEAKER_02: Absolutely, yeah.
• 23:42
  SPEAKER_02: And also it's like, you know what's what's funny and actually remarkable?
• 23:46
  SPEAKER_02: I remember when I first took biochemistry, my professor began the the class with this question.
• 23:51
  SPEAKER_02: He was like, Can any of you tell me what the white of an egg is?
• 23:56
  SPEAKER_02: And everybody was like, What?
• 23:57
  SPEAKER_02: What is he talking about?
• 23:58
  SPEAKER_02: And he was like, What is the white of an egg?
• 24:00
  SPEAKER_02: Why does the why does it turn white when you put it on a skillet?
• 24:04
  SPEAKER_02: And he literally like was trying to explain that when you denature protein, it turns white.
• 24:09
  SPEAKER_02: And that's why you're seeing that white color.
• 24:11
  SPEAKER_02: So it's like, it just kind of goes to show you that, you know, just because something says it's got a lot of protein in it, doesn't mean that one, it's going it's active in the sense of like it's not denatured and it's actually gonna help you.
• 24:23
  SPEAKER_02: And two, like there's a lot of lot more research that needs to be done in this area.
• 24:27
  SPEAKER_02: So um, you know, for all you health nuts out there, you know, just a little fun fact.
• 24:33
  SPEAKER_02: Yeah.
• 24:34
  SPEAKER_02: So I mean, um, you mentioned intermittent fasting as one of the things, uh, one of the four.
• 24:38
  SPEAKER_02: So I would love for us to talk about that.
• 24:40
  SPEAKER_02: I think that's definitely going a big craze right now, too.
• 24:43
  SPEAKER_04: So there actually is some really good, I think, uh, you know, data behind intermittent fasting.
• 24:50
  SPEAKER_04: And I think it's they're finding more out all the time.
• 24:52
  SPEAKER_04: But here's the basics.
• 24:54
  SPEAKER_04: So what you do, it's not about necessarily what you eat, although you should eat, I I believe personally, and they recommend eating low carb, but you restrict your eating to a certain time.
• 25:04
  SPEAKER_04: So it's not about cutting calories.
• 25:07
  SPEAKER_04: So, for example, let's say you have your evening meal at 6:30.
• 25:11
  SPEAKER_04: Yeah, you would wait again to eat for roughly 16 to 18 hours.
• 25:15
  SPEAKER_04: So that would be like 12:30 or 1.30.
• 25:17
  SPEAKER_04: Now, I didn't even know it, but I've been intermittent fasting all of my adult life because I don't like breakfast.
• 25:23
  SPEAKER_04: And so usually I don't eat until around 12:30 or 1.30.
• 25:26
  SPEAKER_04: So it's real easy for me.
• 25:28
  SPEAKER_04: But the the the the reason that intermittent fasting is believed it's important is because it bel they believe that it turns on certain sirtuins, and they think that intermittent fasting may actually equal calorie deprivation.
• 25:49
  SPEAKER_04: So it could extend life without having to go through calorie deprivation.
• 25:53
  SPEAKER_04: Now, this whole calorie deprivation thing, there are actually about 10,000 people in the US that practice calorie deprivation.
• 26:03
  SPEAKER_04: And what they're doing is they're getting a lot of dense nutrition.
• 26:07
  SPEAKER_04: So they're maybe they're taking a lot of nutrition and blending it and literally drinking it because they're only eating about 500 calories a day.
• 26:17
  SPEAKER_04: And I and the problem with that, a study like that, if you want to call it a study, is that it would take a very long time to get data or to really determine anything because you're talking about having to see if these people live to be older than they might have normally.
• 26:37
  SPEAKER_04: And you know, you wonder if you're eating 500 calories a day, if you're living longer, or you just think you're living longer because you're miserable.
• 26:44
  SPEAKER_04: Right.
• 26:45
  SPEAKER_04: So intermittent fasting may be able to duplicate that.
• 26:51
  SPEAKER_04: And what they think is that intermittent fasting creates a very mild stress, and this mild stress turns on sertoans.
• 27:02
  SPEAKER_04: And it's it's interesting, you know, we kind of have a tendency to be very black and white.
• 27:09
  SPEAKER_04: We talk about stress, and stress is bad.
• 27:12
  SPEAKER_04: Well, not all stress is bad.
• 27:14
  SPEAKER_04: Now, if I step on a snail, that snail is not going to recover.
• 27:18
  SPEAKER_04: That's a lot of stress.
• 27:20
  SPEAKER_05: Yeah.
• 27:21
  SPEAKER_04: But very mild types of stressors actually can turn on certain factors and may be very helpful.
• 27:30
  SPEAKER_02: Yeah, yeah.
• 27:31
  SPEAKER_02: Like certain genes get turned on, you know, under different stress types.
• 27:35
  SPEAKER_02: I get that, yeah.
• 27:36
  SPEAKER_02: I mean, that makes sense.
• 27:37
  SPEAKER_02: And also, I think um the the definition of stress is interesting too.
• 27:41
  SPEAKER_02: You know, it's like people they hear stress and they automatically think of like, you know, sweating and anxiety and just you know, cortisol levels through the roof, you know.
• 27:51
  SPEAKER_02: So it doesn't have to be that, yeah.
• 27:53
  SPEAKER_02: So that's interesting.
• 27:55
  SPEAKER_02: But um, you know, that's I'm really interested now, now that you told us about the um the intermittent fasting and the nutrition aspect, about supplementation and how that plays a role in all of this.
• 28:07
  SPEAKER_04: So this is a really tricky area because supplementation is are things that are already um in the marketplace.
• 28:17
  SPEAKER_04: In other words, a pharmaceutical company isn't going to come along and spend$50 million um researching something that they can't patent.
• 28:26
  SPEAKER_05: Yeah.
• 28:27
  SPEAKER_04: So a lot of this is anecdotal, and a lot of it is just not well researched because the money isn't out there.
• 28:33
  SPEAKER_04: But I I'll tell you some of the things that I do believe that these researchers are focusing on, and again, very, very smart, uh, respected researchers.
• 28:44
  SPEAKER_04: Um, so one of them is something called NAD.
• 28:48
  SPEAKER_04: Now, and it goes under the name of NAD.
• 28:51
  SPEAKER_04: That's N is a Nancy, A is an apple, D is a dog plus.
• 28:56
  SPEAKER_04: Okay, so NAD is nicotinamide adenine dinucleotide.
• 29:01
  SPEAKER_04: We talked about that.
• 29:02
  SPEAKER_04: That's those are the things, those are what the sertoans need to function.
• 29:06
  SPEAKER_04: So it's like gasoline for your car.
• 29:08
  SPEAKER_04: NAD plus is nicotinamide rubicide.
• 29:13
  SPEAKER_04: And what this is, this when you take this, it is actually um it's a precursor to NAD.
• 29:24
  SPEAKER_04: So it turns into and it increases the NAD levels.
• 29:28
  SPEAKER_06: Right.
• 29:29
  SPEAKER_04: Now, um what researchers talk about is starting with maybe 300 million milligrams a day and work up to about a thousand milligrams a day.
• 29:39
  SPEAKER_02: Wow.
• 29:40
  SPEAKER_02: I mean that that's really interesting.
• 29:42
  SPEAKER_02: And yeah, that really makes sense uh going back to like the idea of um how you know this is all affecting like the electron transport chain and stuff in the body and it's all mitochondrial based.
• 29:53
  SPEAKER_02: That's really interesting that you can take it as a supplement.
• 29:56
  SPEAKER_02: Um yeah, and and also like um I think I've heard about how there's been a lot of studies done, not in the realm of skin health, but in the realm of like a lot of um, like for example, osteoporosis and a lot of other um, you know, disorders in the body where NAD has been used as a supplement and it's really helped in because it's basically like giving your body the immediate energy it it requires.
• 30:19
  SPEAKER_02: Usually it's like you know, goes through this whole process of breaking down, turning into NAD plus, and then we utilize it, but this is like straight up giving it to you.
• 30:27
  SPEAKER_02: So that's interesting.
• 30:28
  SPEAKER_02: Yeah, that's very cool.
• 30:29
  SPEAKER_04: And you know, it gets a little bit more confusing.
• 30:32
  SPEAKER_04: I'm gonna I'm gonna confuse the issue a little bit more.
• 30:35
  SPEAKER_04: There's something called NMN.
• 30:39
  SPEAKER_04: Now NMN is one down the food chain from NAD.
• 30:45
  SPEAKER_04: So some researchers actually take NNM instead of NAD, and some NAD plus, and some researchers take both.
• 30:54
  SPEAKER_04: One of them is more is believed to have more of an effect on physicality, one is believed to have more of an effect on the brain.
• 31:04
  SPEAKER_04: So a lot of researchers take both, but that's again something that it's kind of feeds Sertoans.
• 31:11
  SPEAKER_04: And what's interesting about NMN is it actually has to turn into NAD in order to have an effect on these sertoans, but there's enough of a subtle difference, apparently, that again, some researchers feel that it's appropriate to take both.
• 31:31
  SPEAKER_04: Um, the other thing is resveratrol.
• 31:34
  SPEAKER_05: Okay.
• 31:35
  SPEAKER_04: Now, resveratrol is a chemical in grapes, and apparently it is more present if you make wine the old-fashioned way, like they do in France, let's say, in certain years.
• 31:49
  SPEAKER_04: Um, but it's not that, you know, that doesn't mean that you know you have a license just to go out and uh gee, I'm gonna drink a lot of wine and get my resveratrol because you'd need to drink about a thousand glasses a day to get what you need.
• 32:01
  SPEAKER_02: Oh wow.
• 32:02
  SPEAKER_04: So think of resveratrol.
• 32:04
  SPEAKER_04: So you think about NAD plus and NMN is like is like the gasoline to make the car go, the seratoins go.
• 32:13
  SPEAKER_04: Think about resveratrol as putting your foot on the gas pedal so the car actually moves.
• 32:20
  SPEAKER_04: And actually, David Sinclair, I mentioned that he wrote the book, uh, Why We Age and Why We Don't Have To.
• 32:27
  SPEAKER_04: He was actually the inventor of resveratrol.
• 32:30
  SPEAKER_04: He sold it for just under a billion dollars to a pharmaceutical firm with the idea that it probably would end up at some point becoming a drug.
• 32:40
  SPEAKER_04: Now, you can go to drugstores, you can go online, you can get NAD, or excuse me, I'm sorry, you can get resveratrol.
• 32:49
  SPEAKER_04: It's not as bioavailable as what Dr.
• 32:54
  SPEAKER_04: Sinclair um actually invented.
• 32:58
  SPEAKER_04: And the the brand out there that I think is one of the best that's done the most research, because some of them just get destroyed in the digestive tract, but it's a brand called Longevinex.
• 33:09
  SPEAKER_04: And they have never even given me one tablet for talking about them so much.
• 33:16
  SPEAKER_04: So I have no I have no financial interest in the company, but it's Longevinex, L-O-N-G-E, V-E-N I uh N-I-X, I think, John.
• 33:27
  SPEAKER_04: V-E-N-I-X, okay, longevinex.
• 33:30
  SPEAKER_04: So Sertuans, or excuse me, long um resveratrol has been shown to have anti-tumor activity.
• 33:37
  SPEAKER_04: It's a very strong anti-inflammatory.
• 33:40
  SPEAKER_04: It's heart protective, it's brain protective, it helps to protect insulin resistance.
• 33:46
  SPEAKER_04: Um, it's believed to be have some protective nature having to do with Alzheimer's.
• 33:54
  SPEAKER_06: Wow.
• 33:55
  SPEAKER_04: That's so interesting.
• 33:56
  SPEAKER_04: It's believed to activate specifically the SAR2 in one gene.
• 34:01
  SPEAKER_02: Yeah, and that's the big one, isn't it?
• 34:03
  SPEAKER_02: It's the one that it's like involved in apoptosis and stuff.
• 34:09
  SPEAKER_02: Wow.
• 34:09
  SPEAKER_02: So that's crazy.
• 34:11
  SPEAKER_04: So, you know, I wish I could get my hands on the actual resveratrol that David Sinclair invented.
• 34:18
  SPEAKER_04: Apparently, he's got a ton of it in his in his basement, and he still takes it.
• 34:23
  SPEAKER_04: What?
• 34:23
  SPEAKER_04: There's only there's only two things that he takes, and that's resveratrol and the NAD NMN.
• 34:32
  SPEAKER_02: Wow, that's nuts.
• 34:34
  SPEAKER_02: That's so cool.
• 34:35
  SPEAKER_02: I would, yeah, I wish you could get your hands on that.
• 34:37
  SPEAKER_04: Give me a puppy.
• 34:39
  SPEAKER_04: And by the way, it's really easy to get NAD plus.
• 34:43
  SPEAKER_04: Um you know that it's it's under patent.
• 34:45
  SPEAKER_04: So essentially, whatever company is manufacturing it, you're getting the same product.
• 34:53
  SPEAKER_04: It just is what I always say is that sometimes companies differentiate themselves by um putting something else in it.
• 35:02
  SPEAKER_04: Like our NAD comes with such and such and such and such.
• 35:05
  SPEAKER_04: You just want to take straight NAD plus.
• 35:09
  SPEAKER_02: Right.
• 35:09
  SPEAKER_02: That makes sense.
• 35:10
  SPEAKER_02: And you know, that's a really cool, you know, thing to know now for everyone listening.
• 35:15
  SPEAKER_02: You know, it's it's definitely helpful when you know what supplements to start going towards.
• 35:20
  SPEAKER_02: And this is actually a huge thing that, you know, I want to actually emphasize in this episode because, you know, I'm a huge, I don't really believe in supplements.
• 35:30
  SPEAKER_02: I won't lie to you, except the ones that actually work.
• 35:34
  SPEAKER_02: If that makes any sense.
• 35:35
  SPEAKER_02: You know, there's a lot of there's a lot of hype out there and people are taking all sorts of things these days.
• 35:40
  SPEAKER_02: But I'm really glad that you you brought this up, Jan, because I think that it's really is time to clarify what is important and not.
• 35:47
  SPEAKER_02: And so, yeah, for everyone listening, if you're a big, you know, really big into this stuff and you're into taking like your vitamins and supplements and what you whatnot, all like you have like 15 bottles of the stuff.
• 35:58
  SPEAKER_02: Maybe you rethink, you know, what do I need and what do I not need?
• 36:02
  SPEAKER_02: You know, and so this is this is really, really good information here.
• 36:06
  SPEAKER_04: Supplements are a slippery slope.
• 36:09
  SPEAKER_04: If you ever take any kind of publications or you know, magazines, like there's a company called Life Extension that makes some very good supplements and they put out a magazine, and they do have some very good data in there and some good research.
• 36:22
  SPEAKER_04: But it's every time they talk about a supplement, it's always, oh my gosh, this is the best supplement in the world.
• 36:27
  SPEAKER_04: This is the one that's gonna save your life, this is the one that's gonna make you live longer.
• 36:30
  SPEAKER_04: And it literally, and it it's it's very seductive.
• 36:33
  SPEAKER_04: And literally, when you start adding all this stuff up, you're taking, you know, 40, 50 different things.
• 36:38
  SPEAKER_04: So um, the other, there's an very interesting company out there called Novos, N-O-V-O-S.
• 36:46
  SPEAKER_04: And they have a really, really um exciting.
• 36:51
  SPEAKER_04: Um I'm gonna say, I guess you could say their uh scientific board is impressive, and they have a lot of respect.
• 37:01
  SPEAKER_04: And one of the things, how they differentiate this, they say a lot of the supplements that we're we're told to take are probably going to enhance our life, but they're not going to extend our life.
• 37:13
  SPEAKER_04: And what is actually going to extend life is something that may be completely different, and that could be things like more like uh NMN, uh um NAD plus, those kinds of things that we, you know, it's not the B vitamins, it's not taking coenzyme Q10, etc.
• 37:31
  SPEAKER_04: But there's just that we really need a lot of research in that area.
• 37:34
  SPEAKER_04: There's just not enough research.
• 37:36
  SPEAKER_04: And again, it's because for the most part, there's no real money in it.
• 37:42
  SPEAKER_04: A pharmaceutical firm isn't going to make a lot of money doing this type of research.
• 37:47
  SPEAKER_02: Yeah, yeah.
• 37:49
  SPEAKER_02: No, I mean, I think that that's it's definitely interesting.
• 37:52
  SPEAKER_02: And I think supplements, you know, there's a lot more work that needs to be done on understanding how the body utilizes specific molecules.
• 38:00
  SPEAKER_02: And that's where I really kind of hesitate, you know, with things that are not uh, you know, out outside of NAD and what we've been talking about here, you know, and I really hesitate there because you can be doing a lot of damage rather than good, you know, if you don't know why this molecule is important for your body.
• 38:17
  SPEAKER_02: So I I think this is a the, you know, this is a much needed information, what you're sharing with us and and a lot of guidance, in my opinion, because there's a lot of people, you know, I'm not kidding, I see it all the time.
• 38:29
  SPEAKER_02: You know, you guys have 15, 20 bottles and you're taking the stuff like it's, you know, like it's your meal supplement or something, and you shouldn't be doing that.
• 38:37
  SPEAKER_02: You know, it's it's just not going to be healthy for you in the long run.
• 38:40
  SPEAKER_04: So, you know, when they talk about a lot of these supplements, they are kind of in a sense a little bit deceiving because they'll talk about various studies.
• 38:48
  SPEAKER_04: And when you really delve into a study, it might be a study that was done on 10 people.
• 38:55
  SPEAKER_04: It might be a study that was done in some little country that you've never even heard of on 10 people for a month.
• 39:04
  SPEAKER_04: And so really you you really have to get into the sort of the underpinnings where the legs grow.
• 39:14
  SPEAKER_04: And um it's I I totally agree with you, is that we need to be careful what we ingest.
• 39:22
  SPEAKER_02: Yeah, absolutely.
• 39:23
  SPEAKER_02: No, absolutely.
• 39:24
  SPEAKER_02: Um, you know, and I want to actually I I want to take the conversation into the anti-aging drugs that you had mentioned in the beginning.
• 39:30
  SPEAKER_02: That's very, very fascinating.
• 39:32
  SPEAKER_02: Could you talk to us about that?
• 39:33
  SPEAKER_04: Well, actually, there is a drug that you can get your hands on right now, it's one of the most common drugs in the world, and it's actually going through uh, I think some FDA oversight in order to be able to uh make the claim as an anti-aging drug, and that's vetformin.
• 39:51
  SPEAKER_04: Yeah.
• 39:52
  SPEAKER_04: Now, metformin uh is a drug for type 2 diabetes, and it's actually been around um in kind of common usage since 1922.
• 40:02
  SPEAKER_04: It went into prescription use in 1972, and studies have just I mean, hundreds of thousands and millions of gazillions of people around the world take this.
• 40:12
  SPEAKER_04: It's just one of the most used drugs, and so it's considered very safe.
• 40:15
  SPEAKER_04: But one of the studies that was done on metformin was done on about 14,000 people, and here's what they found.
• 40:23
  SPEAKER_04: Let's say, for example, that somebody has diabetes.
• 40:27
  SPEAKER_04: Yeah, and let's say they're elderly, and let's say they're also a couch potato and they're overweight and their diet isn't very good, and they don't exercise, and they're taking metformin, they may live three to five years longer than someone else who considers themselves to be bit and have a really good diet.
• 40:47
  SPEAKER_06: Oh wow.
• 40:48
  SPEAKER_04: And so metformin has been found to be protective against heart disease.
• 40:54
  SPEAKER_04: Uh, you know, diabetics are are prone to having heart issues, and it actually has a protective effect.
• 41:02
  SPEAKER_04: Um, protective, and they found definite evidence, protective with regard to Alzheimer's.
• 41:10
  SPEAKER_04: Um it's it's it's extends lifespan, it's protective against many diseases, it significantly lessens inflammation.
• 41:21
  SPEAKER_04: And we're talking about inflammation throughout the body.
• 41:23
  SPEAKER_04: We're talking about inflammation markers.
• 41:25
  SPEAKER_04: I mean, it improves your skin.
• 41:27
  SPEAKER_04: Um it's protective against cancer, uh, in particular, um, well, a number of different cancers, but in particular, prostate cancer, it appears.
• 41:36
  SPEAKER_04: Um, Alzheimer's, it improves energy, it improves vibrance, it improves your skin, your overall feeling of health and well-being.
• 41:43
  SPEAKER_04: And I have to tell you, when I started really researching this, I didn't know this because at the time it was, you know, it it's it's it's still kind of under the radar, but it's becoming more and more mainstream.
• 41:57
  SPEAKER_04: Um, but I found that anytime I would talk to a researcher, they were all on metformin and none of them had diabetes.
• 42:08
  SPEAKER_04: Even my own general practitioner.
• 42:11
  SPEAKER_04: When I called her to ask about trying metformin, and I had this whole kind of speech ready to go about my justification and my research.
• 42:22
  SPEAKER_04: And I got about 30 seconds into it, and she stopped me and she said, Don't even go any further.
• 42:26
  SPEAKER_04: She said, I you you can have it.
• 42:30
  SPEAKER_04: She'd been taking it herself.
• 42:31
  SPEAKER_04: Now, here's what here's one of the reasons why metformin has this effect is because it turns on Sir Tunes.
• 42:42
  SPEAKER_04: Now, okay this is we're we're finding more and more out about this all the time, but but here's what they speculate.
• 42:50
  SPEAKER_04: One of the things that metformin does is it releases tiny amounts of free radicals into cells.
• 42:58
  SPEAKER_04: And that is enough of a stressor that it appears to turn on certain sertuans.
• 43:04
  SPEAKER_04: Now, in terms of how it works in the body with regard to diabetes, you know, we have an enzyme in our liver, and like a lot of things, um if you even if you don't have diabetes, um your blood sugar probably isn't going to be as good at 40 or 50 or 60 as it was when you were 20 or when you were 15.
• 43:24
  SPEAKER_04: And so what and what metformin does is it just prevents the sugar from being dumped, so to speak, into literally every cell in your body.
• 43:33
  SPEAKER_04: And um in in in doing so, it has these, you know, these these effects.
• 43:41
  SPEAKER_04: Now again, this is evolving all the time.
• 43:45
  SPEAKER_04: When I was originally researching this, researchers were saying, well, what you want to do is you want to work up to about a thousand milligrams a day.
• 43:53
  SPEAKER_04: You don't take more than that because more than that for aging isn't going to be effective.
• 43:58
  SPEAKER_04: Now there was a meeting.
• 44:00
  SPEAKER_04: Recently, that my own personal physician went to where they're saying basically you don't need to do more than 500 milligrams a day for anti-aging.
• 44:08
  SPEAKER_02: Hmm.
• 44:09
  SPEAKER_02: Yeah, 500 is the lowest.
• 44:11
  SPEAKER_02: Pardon?
• 44:12
  SPEAKER_04: I think 500 is the lowest.
• 44:13
  SPEAKER_04: You can't prescribe less than 500.
• 44:15
  SPEAKER_04: Yeah.
• 44:15
  SPEAKER_04: I, you know, you could probably, if you're not doing the time release one, you could probably take cut it in half or something.
• 44:20
  SPEAKER_04: But um, and there really, I have to tell you, there really aren't side effects with metformin other than, and again, this is something that you discuss with your physician because you could have certain a certain type of ailment or disease or something where it might not be appropriate.
• 44:37
  SPEAKER_04: But um, other than the fact that some people in the beginning have bloating, um, I'm one of those individuals, and I'm one of the individuals where it didn't go away after four weeks or six weeks.
• 44:52
  SPEAKER_04: I have never run into anybody that has the same problem I have.
• 44:56
  SPEAKER_04: Um, and um, the only other um issue that I've ever heard about, and this is an acquaintance of mine, and she does beautifully on metformin, derives all the benefits, but she gets an upset stomach if she eats sugar.
• 45:11
  SPEAKER_04: Now, maybe that's not the worst thing to have to happen to somebody.
• 45:15
  SPEAKER_05: Yeah.
• 45:16
  SPEAKER_02: What is GI effects?
• 45:18
  SPEAKER_02: Well, it's GI effects in general with metformin, right?
• 45:21
  SPEAKER_02: I mean, that's like the main side effect of metformin.
• 45:24
  SPEAKER_02: You know, you're gonna it's it's harsh on your GI system in the beginning.
• 45:28
  SPEAKER_02: So that makes sense.
• 45:30
  SPEAKER_04: Now, the one thing that you can do, now, believe it or not, um, some physicians that have patients that need to take metformin for diabetes, um, and they have these digestive issues, um, they actually can have metformin compounded.
• 45:44
  SPEAKER_04: What they do is they compound 30% metformin in a cream, and it's placed like on the inner thigh area, and it's absorbed that way, and that bypasses any of those kinds of digestive issues.
• 45:58
  SPEAKER_04: That's interesting.
• 45:59
  SPEAKER_04: Have they wow?
• 46:00
  SPEAKER_04: Wow.
• 46:01
  SPEAKER_04: I didn't know if you could work.
• 46:04
  SPEAKER_04: That works.
• 46:05
  SPEAKER_04: Yes, I wow, that works.
• 46:07
  SPEAKER_04: Now, there's also um another diabetic medication, but it has it's just starting to be um looked at as possibly maybe have an effect having to do with aging.
• 46:20
  SPEAKER_04: And I've only come across one speculative article, but that's Jardiance.
• 46:27
  SPEAKER_05: Okay.
• 46:27
  SPEAKER_04: Now, Jardiance, and the reason why we think that it possibly could have an effect on uh aging is because Jardians is sometimes given along with it's a diabetic medication.
• 46:39
  SPEAKER_04: Yeah, it's it's like metformin, except that it releases the sugar through the kidneys.
• 46:46
  SPEAKER_04: So the side effect of giardiance is that you don't have the digestive issues, but you may go to the bathroom more frequently.
• 46:52
  SPEAKER_04: But it's been shown to decrease death, overall death in diabetics by 30%.
• 46:59
  SPEAKER_04: Wow.
• 47:00
  SPEAKER_04: Um that's crazy.
• 47:02
  SPEAKER_04: So it looks like it's gonna have anti-inflammatory effects, cardiovascular protection, protection Alzheimer's, and longevity and anti-aging benefits.
• 47:12
  SPEAKER_04: Um so it also, again, if somebody is on metformin but they have a tendency to heart issues or whatever, um, it lowers the risk of heart-related death, such as stroke or heart attack.
• 47:28
  SPEAKER_04: It reduces the risk of hospitalization and death due to heart failure.
• 47:35
  SPEAKER_04: Um, they show reduced plaque buildup in blood vessels that oftentimes is caused by high sugar levels.
• 47:44
  SPEAKER_04: It appears to block the action of certain proteins, in particular SGLT-2 proteins, and don't ask me what that is.
• 47:54
  SPEAKER_02: Um that's a glucose transporter, sucrose transporter, yeah.
• 47:58
  SPEAKER_04: But it also helps to um improves weight loss because it's removing glucose and lowering you know the blood sugar.
• 48:06
  SPEAKER_04: Um, so again, more research needs to be done in this area, but I'm going to tell you about something that is really interesting.
• 48:13
  SPEAKER_04: Now, this is not something you that I'm telling anybody they should run out and do.
• 48:17
  SPEAKER_04: There are some people that are doing it, but I think it's fullhardy because there hasn't been enough research.
• 48:22
  SPEAKER_04: But in early studies, and lots of times when they do these studies, we just tell you they're doing them on worms or they're doing them on mice or something like that.
• 48:32
  SPEAKER_04: Yeah.
• 48:32
  SPEAKER_04: Um, they think that this is this will have an effect on humans, and there are some people who are doing it.
• 48:38
  SPEAKER_04: So, what it is is when you look into the future and you look at extending life and extending our health span, it's probably going to be a combination of drugs.
• 48:51
  SPEAKER_04: Here's an example of a combination.
• 48:54
  SPEAKER_04: So, in these studies, they've taken a drug which is rep rifamisin.
• 49:01
  SPEAKER_05: Yeah.
• 49:01
  SPEAKER_04: And rifamocin is an antibiotic given for tuberculosis, and they give it in a very small amount.
• 49:06
  SPEAKER_04: I mean, very small, two milligrams.
• 49:10
  SPEAKER_05: Right.
• 49:10
  SPEAKER_04: Then they take a drug called rapamyosin, and this is another uh antibiotic that's used for organ rejection, and they give it in really low 0.5 milligrams.
• 49:23
  SPEAKER_04: What they found is that it extends lifespan to around as much, it extends lifespan as much as 89%.
• 49:33
  SPEAKER_05: Wow.
• 49:34
  SPEAKER_04: Now, when they add in abantoin, yeah, which is something that's excreted from maggots, but they also use it in skincare, interestingly enough, that extends, uh goes, takes it up to 95%.
• 49:47
  SPEAKER_04: And if they add in metformin, it's even better.
• 49:52
  SPEAKER_02: Wow.
• 49:53
  SPEAKER_02: So it's like a local drug combo or cocktail.
• 49:56
  SPEAKER_04: But again, we don't know the long-term effects.
• 50:00
  SPEAKER_04: And so this is something that really needs to be studied.
• 50:03
  SPEAKER_04: But I guess the point is that there's so much going on that's exciting.
• 50:09
  SPEAKER_04: And that uh gives us a lot of um hope and just um, you know what to look forward to, really.
• 50:19
  SPEAKER_04: Yeah, I mean watching this, watching this unfold.
• 50:22
  SPEAKER_04: And I I've always said, you know, they're also doing a lot of research in the area of how we can clone organs because the it even if you we could extend life significantly, we're just gonna have things that are gonna wear out.
• 50:35
  SPEAKER_04: So, you know, you have to have the research on both ends.
• 50:39
  SPEAKER_02: Absolutely.
• 50:39
  SPEAKER_02: No, that's definitely I completely agree with you.
• 50:41
  SPEAKER_02: It's really exciting stuff.
• 50:42
  SPEAKER_02: And, you know, um, it's so interesting that you bring up this um in the drugs that you mentioned, because you know, we were even learning back when I was still training was that you know, there is a lot of potential for a lot of drugs, such as the TB drugs that you mentioned, such as these very like random, you know, just pharmaceuticals.
• 51:03
  SPEAKER_02: And uh we even were learning back then there's there's a lot of potential here.
• 51:07
  SPEAKER_02: So now, you know, talking now, many years later, we're still on this, you know, this this boat where we're trying to figure out like what is it that's causing this.
• 51:15
  SPEAKER_02: So I I love that you brought that up.
• 51:17
  SPEAKER_02: And I think it's definitely um something I'm looking forward to in terms of seeing like, you know, what they find in long-term cohort studies, because that would be really, really life-changing if they can, you know, no pun intended.
• 51:29
  SPEAKER_04: Well, this professor that I talked to at Stanford University last week, um, I actually met him because he's the father of an acquaintance of mine, and he's considered to be a superager.
• 51:44
  SPEAKER_04: He's just turning 91, still working.
• 51:48
  SPEAKER_04: His team developed a molecule related to metformin.
• 51:52
  SPEAKER_04: So it's not metformin's related to metformin.
• 51:55
  SPEAKER_04: And in their studies, what they showed was that at the studies show that taking that molecule uh for 22 months, you would take it indefinitely, but at 22 months, um, that it literally reverses aging completely.
• 52:12
  SPEAKER_02: Wow.
• 52:13
  SPEAKER_02: Now what about what about skincare then?
• 52:16
  SPEAKER_02: Like the how about applying this to skincare, like de-aging or skin?
• 52:20
  SPEAKER_04: That's one of the reasons I had a conversation because I think that you know, so much of this is applicable topically, but um, you know, you there are some we we actually can de-age our skin.
• 52:32
  SPEAKER_04: Yeah, and I'll tell you, you know, I always say there's there's two things there's quantity of skin and there's quality of skin.
• 52:42
  SPEAKER_04: Right now, quantity of skin, you know, if you just have too much skin and everything is sagging and bagging, I I can't help you a whole lot with that.
• 52:48
  SPEAKER_04: That's probably that's cosmetic surgery, at least at this point.
• 52:51
  SPEAKER_04: But quality of skin is absolutely something that we can address.
• 52:56
  SPEAKER_04: And I will tell you, when we when you look at quantity of skin or you look at things where you really cosmetic surgery, that's only four to five percent of the external aging process.
• 53:11
  SPEAKER_04: It's only four to five percent.
• 53:14
  SPEAKER_04: Wow, that's what we call ext intrinsic aging.
• 53:17
  SPEAKER_04: Extrinsic aging, you look in the mirror and you see, you know, gee, I'm getting fine lines and wrinkles, my pores are looking larger, I have brown spots, my skin looks dull, it looks coarse, et cetera, et cetera.
• 53:30
  SPEAKER_04: That's 90 to 95 percent of what we perceive as the nebula aging, and most of that happened before the age of 10.
• 53:37
  SPEAKER_04: So um when we when we look at that, and and again, it's a really complex issue, but I and I'm gonna oversimplify it.
• 53:46
  SPEAKER_04: But what you're really looking at in terms of what we see visibly is two things.
• 53:52
  SPEAKER_04: One, your stratum corneum, the outer layer, which is a dead layer, and the shell the cells sit like shingles on a roof, like fish scales, and they literally should be in a very cohesive manner.
• 54:04
  SPEAKER_04: You know, it's kind of like your your hair.
• 54:07
  SPEAKER_04: The outside of your hair is known as the cuticle layer.
• 54:10
  SPEAKER_04: And when that cuticle layer is really tight and organized, it's your hair is so shiny and reflective.
• 54:17
  SPEAKER_04: But if you do a lot of chemical treatments and the cuticle layer gets all roughed up, it looks all dull and dry and damaged.
• 54:23
  SPEAKER_04: Same thing with your skin.
• 54:24
  SPEAKER_04: Now, with our skin, though, our hair is dead, our skin is alive, and we shed about 500 million of these cells a day throughout our whole body.
• 54:32
  SPEAKER_04: They're microscopic.
• 54:33
  SPEAKER_04: But as we get older, and you know, starting around the age of 20, those cells begin to pile up and they get very disorganized.
• 54:43
  SPEAKER_04: And in between these cells, we're supposed to have these really hygroscopic substances, mucopolysaccharides and ceramides, and phospholipids, and hyaluronic acid, and it gives the skin a lot of barrier function, makes it nice and plump and and soft and radiant.
• 54:57
  SPEAKER_04: Um, we start losing those substances.
• 54:59
  SPEAKER_04: We don't produce them to the same extent.
• 55:02
  SPEAKER_04: Um and then so what we want is we want a really nice, thin, compact stratum corneum with lots of those substances.
• 55:12
  SPEAKER_04: The other thing that happens is our collagen, and our dermis is 80% collagen, our dermis gets thinner.
• 55:19
  SPEAKER_04: So our stratum corneum gets thicker, gets disorganized, our dermis gets thinner.
• 55:23
  SPEAKER_04: We want to reverse that.
• 55:25
  SPEAKER_04: And the other the third aspect of this is the instructions coming from our DNA.
• 55:32
  SPEAKER_04: Now your genes are made up of DNA, and some of your genes are expressive genes, and so they express instructions.
• 55:40
  SPEAKER_04: The only instructions the body listens to.
• 55:43
  SPEAKER_04: So whether you have a broken bone or a sunburn or you have a you know something else that's the disease or something, you're you're not going to get any better unless those instructions are able to tell your body what to do and achieve some normalcy.
• 56:02
  SPEAKER_04: Now, by the way, there is even talk about that we may have a kind of like a computer where there is a another hard drive in there with a completely um uncompromised set of instructions, and we may be able to reboot it every few years.
• 56:21
  SPEAKER_04: Really?
• 56:22
  SPEAKER_04: About that as well, but that's a whole other story.
• 56:23
  SPEAKER_04: But at any rate, um so so what happens when we're born is these instructions are so perfect and they really repair beautifully throughout our childhood and our teenage years.
• 56:36
  SPEAKER_04: And then when we hit go into a catabolic state around you know the age of 20 or so, there's there's enough that's compromised due to sun exposure and just daily living and diet and all of the other things that the challenges that we have, that those instructions are start to become more and more compromised.
• 56:56
  SPEAKER_04: And that's what we see is the aging process, both internally and externally.
• 57:01
  SPEAKER_06: Right.
• 57:02
  SPEAKER_04: So the thing that I'm gonna say, there's what we want to do topically is we want to keep a nice, thin, compact stratum cornea.
• 57:15
  SPEAKER_04: We want to keep a nice thick dermis, and there's things that we can do to resurface the skin, and you know, there's there's some really good technologies out there, and particularly retinoids that can actually reverse the instructions coming from your DNA.
• 57:27
  SPEAKER_04: And that's not just me saying that, that's 50 years of medical research, but there's something else that is really fascinating as well.
• 57:36
  SPEAKER_04: I actually have a patent on this, and uh it's a product that we make that is used along with retinoids and used along with our skincare management system.
• 57:44
  SPEAKER_04: It's called regeneration booster.
• 57:46
  SPEAKER_04: Actually, the full name is age intervention regeneration booster, but that's a long name, so I call it regeneration booster.
• 57:53
  SPEAKER_02: Um I love that product, by the way.
• 57:57
  SPEAKER_04: I do too.
• 57:58
  SPEAKER_04: Yeah, it has a really good one with telomeres and telomerase enzyme.
• 58:06
  SPEAKER_04: Now, telomeres come off the end cap of your DNA, they look like shoelaces.
• 58:12
  SPEAKER_05: Yeah.
• 58:13
  SPEAKER_04: And the end of the telomere looks like the end of the shoelace, like that's the plastic thing that's known as the telomerase enzyme.
• 58:20
  SPEAKER_04: And the telomerase enzyme has got a lot of genetic material and it has um chromosomal material and it helps to keep the telomere kind of stable.
• 58:29
  SPEAKER_04: And also can when there's fluctuation, it can kind of help the telomere sometimes add a little bit more length, but help to keep it stable.
• 58:37
  SPEAKER_04: And why is this important?
• 58:38
  SPEAKER_04: Well, telomeres are kind of like the granddaddy control panel of everything, and we know that telomeres as they they shorten as you age, and when they get real short, you lose the ability to repair, you lose a month immune function, and you you pass on.
• 58:59
  SPEAKER_04: Now, the Nobel Scientific Prize was awarded a number of years ago to three physicians for their work in telomeres and telomerase enzyme as they relate to aging and longevity.
• 59:09
  SPEAKER_04: And we now know that progeria, that aging disease that children get that that are born with, that where they literally look like little old people and they don't live much past, you know, 12, 13 or so years old.
• 59:27
  SPEAKER_04: They don't get their full height, they don't get hair, they have opportunistic diseases.
• 59:31
  SPEAKER_04: We know that they're born old, they're born with short telomeres.
• 59:35
  SPEAKER_04: Yeah.
• 59:35
  SPEAKER_04: I actually had the pleasure of talking with uh one of the foremost experts at Stanford University on that subject and some of the things that they're working on with regard to that.
• 59:44
  SPEAKER_04: But their telomeres just like they're they're just born with short telomeres.
• 59:49
  SPEAKER_04: Now, this is a goes back before the Nobel Scientific Prize was awarded.
• 59:56
  SPEAKER_04: I was reading an obscure study, and I have a whole little bunch of books behind me on telomeres and telomerase enzymes.
• 1:00:05
  SPEAKER_04: Right.
• 1:00:06
  SPEAKER_04: I happened to come across a study in which they soak skin cells in telomerase enzyme and they never aged, they became immortal.
• 1:00:15
  SPEAKER_04: Now, not at that point, I can't give you mortal cells.
• 1:00:21
  SPEAKER_04: But, and actually, way back when I was first working with Booster, I actually worked with the actual telomerase enzyme, but it's not as bioavailable.
• 1:00:30
  SPEAKER_04: And now what we work with is we work with something called cyclostrogenol.
• 1:00:35
  SPEAKER_04: Now, cyclostrogenol comes from the oestroglis plant, and it works on I think it's C D3, CD4 cells, but it has the ability to actually have an effect on telomeres, and it helps to sort of stabilize them and may give a little bit of length.
• 1:00:53
  SPEAKER_04: Telomeres are fluid.
• 1:00:56
  SPEAKER_04: If you have a disease or you have a um something that happens in your life that maybe affects you emotionally, stressfully, your telomeres can actually shorten.
• 1:01:10
  SPEAKER_04: But if you improve your lifestyle, if you're able to recover, uh your telomeres can actually kind of lengthen again.
• 1:01:17
  SPEAKER_04: Now, eventually they're going to get short over time, but you can stabilize them, and sometimes you can even add a little bit of length.
• 1:01:25
  SPEAKER_04: And cyclostrogenol has actually been shown to have that ability to stabilize and maybe actually act add a little bit of length.
• 1:01:33
  SPEAKER_04: And so what I liken it to is kind of being able to turn back the skin's aging clock.
• 1:01:40
  SPEAKER_04: Now we're not going to turn it back to when you're 15, but it allows your skin to function in a way that it did when it was younger.
• 1:01:51
  SPEAKER_04: And also in that product, we have um growth factors, transferring growth factor beta 1, a keratinocyte growth factor, which helps with volume.
• 1:02:01
  SPEAKER_04: Um we have epidermal growth factor, we have lots of peptides and anti-inflammatories.
• 1:02:06
  SPEAKER_04: So it's just a really um tremendous, in my opinion, um product to be able to address the signs of aging.
• 1:02:18
  SPEAKER_02: Yeah.
• 1:02:18
  SPEAKER_02: No, it really, and you know, that's amazing that you found that because, you know, the telomerase and this the this conversation around around telomeres was something I remember like when I first started skinarchy, I had this conversation with the founder, and I we were literally laughing because like, unless you can figure out a way to inhibit telomerase enzymes and you know, like just figure out how to like stop that whole process.
• 1:02:40
  SPEAKER_02: I don't really believe you when you say anti-aging.
• 1:02:42
  SPEAKER_02: You know what I mean?
• 1:02:43
  SPEAKER_02: So like that's it's really ironic that this coming full circle for me on the podcast because that's that's really, really revolutionary, you know.
• 1:02:51
  SPEAKER_02: And and I really love that product, by the way, for everyone listening.
• 1:02:54
  SPEAKER_02: I mean, I use it uh regularly, so I can attest to how amazing it is.
• 1:02:59
  SPEAKER_02: So, but yeah, that's amazing, Jan.
• 1:03:01
  SPEAKER_02: I mean, I always learn so much when I talk to you.
• 1:03:03
  SPEAKER_02: I think I've said this before.
• 1:03:05
  SPEAKER_02: And um, I hope everyone tuning in, I hope you, you know, really learned something again with this episode.
• 1:03:11
  SPEAKER_02: But this is really, really fascinating stuff.
• 1:03:13
  SPEAKER_02: And a lot of the topics you brought up, like, you know, um, I really encourage people listening to look it up, you know, and do your do your homework because it's a lot of science, but it's worth reading about.
• 1:03:23
  SPEAKER_02: So I I really appreciate you bringing it up, Jan, and I love this episode so much.
• 1:03:27
  SPEAKER_04: Thank you.
• 1:03:28
  SPEAKER_04: Well, it's a lot of fun to talk about, and I really appreciate having the opportunity.
• 1:03:33
  SPEAKER_02: Thank you so much.
• 1:03:34
  SPEAKER_02: And everyone tuning in, please make sure that you give us your comments, feedback, um, and everything, like in terms of reviews, and that means the world to us.
• 1:03:42
  SPEAKER_02: So I would really appreciate it.
• 1:03:44
  SPEAKER_02: But thank you, and I will be back next time.
• 1:03:46
  SPEAKER_02: Yes, can't wait.
• 1:03:51
  SPEAKER_02: Hey guys, so I hope you love that episode.
• 1:03:54
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• 1:04:16
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• 1:04:37
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• 1:04:47
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• 1:04:58
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