1215-Mitochondrial Tracing of Innate Immune Clonal Dynamics
This study introduces Mitotrek, a novel computational framework that utilizes mitochondrial DNA mutations to track the ancestral lineages of innate immune cells in cancer patients. By analyzing these genetic markers alongside chromatin accessibility, researchers discovered that the specialized roles of tumor-infiltrating monocytes are often predetermined in the blood before they even enter the tumor site. The data reveal that while local tumor signals trigger general cell maturation, the specific decision to become a dendritic cell or a macrophage is guided by epigenetic programming…
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