153-Cross-tissue multicellular coordination in cancer

Paper Talk · Oct 21, 2025 · 16m

This paper introduces a new computational framework, CoVarNet, designed to systematically identify cross-tissue coordinated cellular modules (CMs) using single-cell transcriptomic data from both healthy human tissues and diverse cancer types. The researchers compiled extensive pan-tissue and pan-cancer single-cell atlases to define these CMs, which represent fundamental units of multicellular organization. By applying this framework, the study reveals how these CMs function in tissue homeostasis, showing dynamics related to factors like aging (e.g., in the spleen) and menopausal transitions…