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The Mole That Healed Then Vanished: DOET's Lost Miracle Drug
The Mole That Healed Then Vanished: DOET's Lost Miracle Drug
A buried 1960s compound produced euphoria, talkativeness, and a day-long energizing clarity in volunteers at doses smaller than a single grain of table salt - and not one person hallucinated. How did a molecule with a clean clinical profile, a corporate patent, and Johns Hopkins trials end up illegal alongside heroin, and what did that decision mean for medicine?
In this episode, we tell the story of DOET from its synthesis at Dow Chemical to human trials at Johns Hopkins, tracing Alexander Shulgin’s chemical tweak, the published…
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