397-Spatial Mapping of Human and Mouse Pulmonary Fibrosis
This research article utilized spatial transcriptomics to examine the complex cellular environments of idiopathic pulmonary fibrosis (IPF) in both human patients and mouse models. By mapping gene expression across lung tissues, the authors identified aberrant basaloid epithelial cells in humans and their counterparts in mice, providing new insights into how these cells drive irreversible scarring. The study highlights a critical difference in disease progression, showing that alveolar regeneration is successful in mice but becomes stalled or dysfunctional in human IPF. Researchers also…
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