629-Architecture of Hantavirus Glycoprotein Tetramers
The paper details a scientific study on the Andes virus (ANDV), a dangerous hantavirus, and the development of high-resolution structural models of its glycoprotein assembly. Researchers utilized virus-like particles (VLPs) and cryo-electron microscopy to reveal the near-atomic architecture of the viral surface, identifying how glycoprotein tetramers organize into a lattice. These structures clarify how the virus senses acidic environments to trigger membrane fusion and how specific neutralizing antibodies, such as ADI-65534, bind to the virus. Furthermore, the study explores a…
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