1149-Chromatin Remodeling in Cancer Dedifferentiation

Paper Talk · Jun 18, 2026 · 16m

This study investigates how melanoma cells escape treatment by transitioning into drug-tolerant persister states through a process of reversible dedifferentiation. By analyzing multi-omics data, the researchers identified that this transition is driven by two sequential transcriptional waves that orchestrate a global reconfiguration of the chromatin landscape. The first wave is triggered by oxidative stress following oncogene inhibition, which leads to NF-κB/RelA activation and the recruitment of histone-modifying enzymes. These early epigenetic changes then silence critical lineage-defining…