470-Integrated Multimodal Spatial Omics Mapping via DBiTplus
The paper details the development and application of DBiTplus, an advanced multi-omics platform designed for spatial transcriptomic and proteomic mapping within the same tissue section. This methodology improves upon previous techniques by using microfluidic barcoding and thermostable RNase H to achieve high-quality cDNA recovery while maintaining tissue integrity. Researchers successfully applied this tool to mouse embryos and human lymphoma tissues, enabling the identification of distinct cellular clusters that correspond to specific anatomical regions. By integrating multiplexed…
The skinny
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