1466-Single-Cell Multiomics of Neuronal Activation

Paper Talk · Aug 21, 2026 · 21m

This research article details a large-scale study on single-cell multiomics to understand how neuronal activation reveals the genetic foundations of neuropsychiatric disorders (NPD). By stimulating human-derived neurons and analyzing their gene expression and chromatin accessibility, researchers identified thousands of context-specific genetic variants that are invisible in resting states or postmortem brains. The results highlight that activity-dependent processes, particularly those related to cholesterol and lipid metabolism, are critical to the development of conditions like schizophrenia…