1142-Spatial Cell Interactions in HER2+ Breast Cancer

Paper Talk · Jun 17, 2026 · 22m

This study utilizes Spatial Transcriptomics (ST) to investigate the complex cellular landscapes of HER2-positive breast cancer across 36 tissue sections. By integrating spatial gene expression with single-cell data, researchers identified distinct molecular signatures and mapped the precise locations of various immune and tumor cell types. A significant discovery includes a type I interferon response occurring where specific macrophages and T-cells colocalize, suggesting a coordinated immune interaction. Furthermore, the authors developed a predictive model to identify tertiary lymphoid-like…