135-Proteomic Networks Drive AD's Pathogenesis

Paper Talk · Oct 13, 2025 · 22m

This article presents research on Alzheimer’s disease (AD) pathogenesis using multiscale proteomic network modeling that integrates extensive proteomic and genetic data from vulnerable brain regions like the parahippocampal gyrus. Researchers identified hundreds of co-expressed protein modules and a key glia-neuron subnetwork strongly linked to AD progression. Through Bayesian causal network analysis, the study pinpointed key driver proteins (KDPs) of the disease, including AHNAK, an astrocytic driver. Experimental validation using human induced pluripotent stem cell (iPSC)-derived brain…