1052-The GGPP-RAB35 Axis in Tfh Cell Regulation
The research identifies the mevalonate (MVA) pathway and its derivative, GGPP, as critical regulators of T follicular helper (Tfh) cell differentiation and function. Scientists discovered that the enzyme GGTase II uses GGPP to modify RAB35 proteins, a process essential for recycling the CXCR5 receptor to the cell surface so Tfh cells can interact with B cells. This metabolic axis is driven by T cell receptor (TCR) signaling and is found to be overactive in patients with systemic lupus erythematosus (SLE). By applying pitavastatin, the researchers were able to block this pathway, reducing the…
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