584-GPLD1 and TNAP Regulation of Cognitive Function in Aging
This research explores how exercise-induced blood factors, specifically the enzyme GPLD1, can combat brain aging and cognitive decline. The study identifies tissue-nonspecific alkaline phosphatase (TNAP) as a critical regulator of the blood-brain barrier, noting that excessive levels of this enzyme impair vascular integrity and memory. By increasing liver-derived GPLD1 or pharmacologically inhibiting TNAP, researchers were able to reverse age-related inflammatory signatures and improve learning in elderly mice. These interventions also showed promise in Alzheimer’s disease models…
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