234-Spatial Niches in Diffuse Large B Cell Lymphoma

Paper Talk · Nov 16, 2025 · 19m

The article details a multi-modal spatial characterization of tumor immune microenvironments in diffuse large B-cell lymphoma (DLBCL). Researchers used highly multiplexed spatial transcriptomics (CosMx) and proteomics (CODEX) on 78 DLBCL tumors to define seven distinct cellular niches characterized by unique cell compositions and communication patterns. The study reveals that the functional states of T-cells and tumor B-cells differ significantly based on the niche they inhabit, with T-cells in specific niches showing varying levels of cytotoxicity and exhaustion markers. Furthermore, the…