157-TPCPA: The Pan-Cancer Proteome Atlas

Paper Talk · Oct 22, 2025 · 16m

This article presents the creation and analysis of The Pan-Cancer Proteome Atlas (TPCPA), a comprehensive mass spectrometry-based landscape of proteins across 22 cancer types from nearly a thousand human samples. This extensive proteomic resource, detailed by authors Knol et al., identifies pan-cancer and cancer type-specific proteins, leading to the discovery of potential biomarkers and therapeutic targets. Key findings include the development of a multi-cancer classifier for identifying the origin of metastases and the identification of protein markers associated with colorectal cancer…