1382-Primate Spermatogonia Generation from Stem Cells
This research presents a novel xenogeneic reconstituted testis (xrTestis) system designed to differentiate human and rhesus macaque induced pluripotent stem cells (iPSCs) into advanced male germ cells. By integrating stem-cell-derived primordial germ cells with mouse testicular somatic cells and transplanting them into immunodeficient mice, the authors successfully generated spermatogonia and early preleptotene spermatocytes. These induced cells closely mirror the transcriptomic and phenotypic profiles of natural primate germ cells, achieving developmental milestones such as prepachytene…
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