463-Spatial Predictors of Immunotherapy Response
This research study utilizes imaging mass cytometry to map the complex cellular landscape of triple-negative breast cancer and identify markers that predict success with immunotherapy. By analyzing nearly two million cells from patients in a randomized trial, scientists discovered that the spatial organization and proliferation of specific immune cells before treatment are primary indicators of a positive response. The study highlights how the multicellular structure of a tumor evolves during therapy, noting that high levels of proliferating T cells correlate with recovery. Conversely, the…
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