628-The Cellular Orchestra of CAR T Success in Myeloma
This paper examines a longitudinal single-cell atlas that identifies the biological drivers behind the success or failure of BCMA-targeted CAR T cell therapy in multiple myeloma patients. The research highlights that long-term remission is not determined by cell dose, but rather by specific T cell phenotypes, particularly the presence of cytotoxic CD4+ T cells and memory-biased states. It also redefines cell exhaustion, noting that dysfunctional T cells often show mitochondrial issues and specific markers like TIGIT rather than traditional exhaustion signals. Furthermore, the study identifies…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.