Latest / Pharmacy Podcast Network / KIDs List Lowdown | Pediatric Pharmacist Review
Transcript
- 0:07Speaker 1: Thanks for listening to the Pharmacy Podcast Network.
- 0:19Speaker 2: Hey, Adverse drug reactions are ADRs are a serious issue
- 0:29Speaker 2: in healthcare today.
- 0:30Speaker 3: The pharmacist is the last line of defense to help
- 0:33Speaker 3: prevent ADRs. A rising role of the pharmacist is the
- 0:37Speaker 3: specialist who focuses on our children. Pediatric pharmacy ensures safe
- 0:41Speaker 3: and effective drug use and optimal medication therapy outcomes and
- 0:45Speaker 3: children up to eighteen years of age. Currently, there are
- 0:48Speaker 3: more than one four and fifty board certified pediatric pharmacy
- 0:52Speaker 3: specialists known as BPS. If you're interested in this expanding
- 0:57Speaker 3: field of pharmacy, this podcast is for you. All Right, everyone,
- 1:01Speaker 3: let's give it up for our host.
- 1:04Speaker 4: Welcome to the Pediatric Pharmacist Review. I am Justin Cole,
- 1:08Speaker 4: and I am here with my co host Mary Vong. Mary,
- 1:11Speaker 4: how you been even great?
- 1:13Speaker 5: Super busy, but it's all great kinds of busy because
- 1:15Speaker 5: we're out here helping kids. How are you, Justin?
- 1:18Speaker 6: I am doing well.
- 1:19Speaker 4: And one of the things, of course we have in
- 1:21Speaker 4: common and many of you podcast listeners do, is.
- 1:23Speaker 6: Exactly what you said.
- 1:24Speaker 4: We are here for the kids, and I'm excited about
- 1:27Speaker 4: this next podcast episode that is also all about the
- 1:30Speaker 4: kids in particular drug safety as we care for them. Well,
- 1:34Speaker 4: so if listeners you go back in the archives of
- 1:37Speaker 4: the Pediatric Pharmacist Review, you're going to find another podcast
- 1:41Speaker 4: about something called The Kids List. And so today we've
- 1:45Speaker 4: brought two of the authors back on the podcast with us,
- 1:48Speaker 4: both Rachel Myers and Dave Hoff, and they are here
- 1:51Speaker 4: to talk about the new updates to the next version
- 1:54Speaker 4: of the Kids List. So I'm excited to have them back.
- 1:57Speaker 4: Dave and Rachel, thanks for joining us today. Thanks for
- 2:00Speaker 4: having us.
- 2:01Speaker 1: We're excited about it.
- 2:03Speaker 6: Great. Well, let's do this again.
- 2:05Speaker 4: You could go back a few podcasts to listen to
- 2:08Speaker 4: Dave and Rachel talk about themselves, but we're going to
- 2:10Speaker 4: give them an opportunity again.
- 2:12Speaker 6: So how about this.
- 2:13Speaker 4: Dave, could you start us off and tell us a
- 2:15Speaker 4: bit about your background and how you ended up having
- 2:18Speaker 4: the vision for and working on the original Kids List?
- 2:21Speaker 7: Sure, right now, justin. I'm a pharmacy consultant. I've been
- 2:26Speaker 7: doing that for about a year. Prior to that, I
- 2:29Speaker 7: worked at Children's Minnesota. I was pharmacy director there for
- 2:32Speaker 7: about a year and a half, Director of clinical Pharmacy
- 2:35Speaker 7: for a year and a half and then it was
- 2:38Speaker 7: some twenty three years. I was a clinical leader clinical
- 2:41Speaker 7: coordinator type individual, and I did most of my work
- 2:46Speaker 7: in critical care, but my work did span the whole
- 2:49Speaker 7: pharmacy spectrum. So going back, we can look back all
- 2:54Speaker 7: the way to the early nineteen nineties. The Beers criteria
- 2:58Speaker 7: was generated by doctor Beer's for the elderly population, so
- 3:04Speaker 7: medications that are potentially inappropriate for use in the elderly.
- 3:08Speaker 7: And when I came out of pharmacy school and I
- 3:11Speaker 7: began working, the first thing I did was I tried
- 3:15Speaker 7: to think of some medications that you shouldn't use in
- 3:17Speaker 7: kids because they're just dangerous. I remembered in school there
- 3:21Speaker 7: were probably five or six that I was taught we
- 3:25Speaker 7: shouldn't use in wine. And I thought, for sure there
- 3:28Speaker 7: was a there's a publication somewhere that had this list.
- 3:33Speaker 8: It was definitive.
- 3:35Speaker 7: But I found that no list existed at the time.
- 3:39Speaker 7: And this is pre internet days, so I thought, well,
- 3:41Speaker 7: maybe it's out there. I just didn't know, Okay, dating myself,
- 3:45Speaker 7: Rachel's shuckling, but you know, I just kind of assembled
- 3:50Speaker 7: medications in my head from other pharmacists and docs, and
- 3:56Speaker 7: I thought those were the medications, and so that really
- 3:59Speaker 7: kind of form the basis for where I'm coming from
- 4:02Speaker 7: for wanting a list for pediatrics.
- 4:04Speaker 8: It is because there was.
- 4:06Speaker 7: No list for kids, and we really needed one for
- 4:09Speaker 7: the kids so that we can improve medication safety.
- 4:15Speaker 4: Well that's great, and I have to say we have
- 4:17Speaker 4: a way better name and acronym for the pediatric list
- 4:21Speaker 4: than the Beers criteria do. Right, named after of course
- 4:24Speaker 4: a physician, but the kid's list just fits so well,
- 4:28Speaker 4: so memorable, So it's amazing.
- 4:30Speaker 6: Anyway, let's turn to Rachel.
- 4:31Speaker 4: Rachel, tell us a bit about yourself and how you
- 4:34Speaker 4: got to working on the kids list.
- 4:38Speaker 1: Sure, so, I'm Rachel Myers.
- 4:40Speaker 9: I'm a clinical professor at Rutgers University's Ernest Mario School Pharmacy,
- 4:45Speaker 9: and I'm a pediatric pharmacist. My practice site is at
- 4:49Speaker 9: Cooperman Barnabas Medical Center in upstate New Jersey. And I
- 4:54Speaker 9: guess I think I was in the right place at
- 4:56Speaker 9: the right time when Dave started talking about making this list.
- 5:00Speaker 9: I think the timing was I was the chair of
- 5:03Speaker 9: the Advocacy committee at PPA and so heard about these
- 5:07Speaker 9: discussions and asked if I could be part of it,
- 5:09Speaker 9: and was just excited to jump in on that project.
- 5:13Speaker 9: It was a big project, but I think it's been
- 5:16Speaker 9: very valuable and really exciting to be.
- 5:18Speaker 1: A part of.
- 5:21Speaker 5: Super exciting. So it's so great to have you both here.
- 5:24Speaker 5: So we talked a little bit about the history of
- 5:26Speaker 5: the Beer's List. What does the Kids List stand for?
- 5:29Speaker 5: Because I know that kids, it's cute, we love kids,
- 5:32Speaker 5: but I know it has a fun name behind it, you.
- 5:35Speaker 7: Know, Rachel, it's the key and appropriate Drugs in Kids,
- 5:41Speaker 7: lest in children lesson.
- 5:43Speaker 8: That's pretty much what it stands.
- 5:44Speaker 9: For, right, Yeah, it took us a long time to
- 5:47Speaker 9: come up with that. Kelly Mattson from the University of
- 5:50Speaker 9: Rhode Island was actually the one who came up with it.
- 5:53Speaker 9: It took a lot, I don't know what was it,
- 5:54Speaker 9: six months or so. We kept going back and forth
- 5:56Speaker 9: with different names, but she's the one that came up with,
- 6:00Speaker 9: uh yeah, keep potentially inappropriate drugs and pediatrics, which you know, yeah,
- 6:05Speaker 9: got us our acronym of kids.
- 6:07Speaker 8: I think it was the hardest thing we did as
- 6:09Speaker 8: a group.
- 6:10Speaker 5: Yeah, compiling the literature not not hard, but naming things.
- 6:14Speaker 5: But we definitely feel the same with perfecting peeds anytime
- 6:17Speaker 5: we renamed platforms or anytime like for the logo. It
- 6:21Speaker 5: was super hard trying to redo it. So funny thing
- 6:24Speaker 5: with perfecting peds. Some people don't know that ped s's
- 6:27Speaker 5: peeds like pediatric, and they think it's peeds like pedicure.
- 6:30Speaker 5: So a lot of people would ask us if we
- 6:32Speaker 5: did FEE. So Jenna made it an urgent matter about
- 6:35Speaker 5: a year ago to rebrand and to change the logo,
- 6:38Speaker 5: so people knew for a fact that we didn't do feed.
- 6:41Speaker 5: So sorry for that squirrel.
- 6:44Speaker 6: But when you were going.
- 6:45Speaker 5: Through this, I know that the hardest part was naming it,
- 6:47Speaker 5: But how do you did you actually go through and define,
- 6:49Speaker 5: like what was your criteria for defining these potentially inappropriate medications?
- 6:55Speaker 4: Sure?
- 6:56Speaker 9: Dave, do you want to start with how we did
- 6:57Speaker 9: it originally? And I could talk about how we did
- 6:59Speaker 9: the second edition?
- 7:01Speaker 7: Sure, I think maybe we'll just kind of get to
- 7:04Speaker 7: methods if you want to start there. You know, with
- 7:08Speaker 7: the first kids list, we assembled a group of individuals
- 7:12Speaker 7: with different pharmacy clinical backgrounds really, and these were individuals
- 7:16Speaker 7: that were recommended by the board at PPA, and and
- 7:19Speaker 7: we got a group together and then we said, hey,
- 7:21Speaker 7: we need a couple more in these areas, and we
- 7:23Speaker 7: did that and that's kind of how we got the
- 7:25Speaker 7: first group. And then with the second edition, we've added
- 7:29Speaker 7: some additional sub specialties impeds to our group, so we
- 7:34Speaker 7: have emergency department and psych and some other and safety
- 7:39Speaker 7: added to our group.
- 7:41Speaker 8: But really what we did is we have.
- 7:44Speaker 7: We've taken a methodological approach to identifying the medications that
- 7:51Speaker 7: might be highest risk of kids. So what we're talking
- 7:55Speaker 7: about is adverse drug reactions in children that are more
- 7:59Speaker 7: common in children then in adults. Okay, these are this
- 8:03Speaker 7: isn't just a list of adverse drug reactions that happen
- 8:06Speaker 7: in kids, but these are specifically ones that happened more
- 8:10Speaker 7: commonly in adults. And so we did a literature search,
- 8:14Speaker 7: We did a PubMed search, and we searched for several
- 8:18Speaker 7: specific criteria looking for an adverse drug reaction a d
- 8:22Speaker 7: R and so on. So we looked at that, We
- 8:26Speaker 7: looked at UH an up to date lexi so back
- 8:31Speaker 7: you know, the Pediatric lexi comp database. They allowed us
- 8:35Speaker 7: access to the database and we queried their database UH
- 8:40Speaker 7: Walter Walter's Cluer's database for certain triggers like caution and
- 8:45Speaker 7: avoid and you know those kinds of things in the
- 8:49Speaker 7: Lexi database. We also went to the fd A Alerts,
- 8:54Speaker 7: So the f d A has a place on the
- 8:58Speaker 7: website that caught against you certain alerts and warnings. We
- 9:03Speaker 7: picked out the ones that were specific for pediatrics. We
- 9:06Speaker 7: added those to the baseline list. And then finally we
- 9:10Speaker 7: all had a list of medications in our own heads.
- 9:14Speaker 7: Not surprisingly, everybody's list was different, very different in some cases,
- 9:20Speaker 7: but we all had our list. And so I think,
- 9:22Speaker 7: I don't know, I might have had I don't know,
- 9:25Speaker 7: thirty or something, and then Rachel probably had thirty.
- 9:28Speaker 1: And the years was the longest day, seventy one.
- 9:32Speaker 7: I don't know what it was, but yeah, So from
- 9:36Speaker 7: these different places we had, we had a strict methodological
- 9:42Speaker 7: approach to identifying what might constitute one of these medications
- 9:47Speaker 7: that would be higher risk, and then we pulled the articles.
- 9:52Speaker 7: We had two individuals review each article using was it
- 9:58Speaker 7: the Prisma techn and so we identified articles that might
- 10:04Speaker 7: be might indicate that a kid would have a higher
- 10:06Speaker 7: risk of ADR than an adult, and only one that
- 10:11Speaker 7: reviewer needed to agree on that, and once we got
- 10:17Speaker 7: agreement on that, we pulled the article. We read the
- 10:19Speaker 7: whole article and then only one of the reviewers needed
- 10:22Speaker 7: to agree on that to submit it to the full group,
- 10:25Speaker 7: and then the fund began. We sat down as a
- 10:29Speaker 7: group and we hashed it out. We kind of talked
- 10:32Speaker 7: about the medications and the relative merits of what we're
- 10:36Speaker 7: seeing in the study versus what we see in practice,
- 10:39Speaker 7: and then that's how we came up with the list.
- 10:47Speaker 9: And then I guess I'll talk about how we came
- 10:49Speaker 9: up with the second list, which is hopefully we'll be
- 10:51Speaker 9: published in the coming months. Basically, we obviously had a
- 10:55Speaker 9: good starting place because we had our published list, and
- 10:58Speaker 9: fortunately we had written and down the date that.
- 11:02Speaker 1: We did our our literature search the first.
- 11:05Speaker 9: Time, so we knew what date to go back to
- 11:07Speaker 9: when we did our literature search the second time. So
- 11:11Speaker 9: we did again second literature literature search. We looked at
- 11:14Speaker 9: LEXI again, we looked at the FDA database again. And
- 11:18Speaker 9: then I think, in my opinion, what kind of made
- 11:21Speaker 9: the biggest change the second go round was just feedback
- 11:24Speaker 9: from pharmacists, you know, from PPA members. You know, I
- 11:28Speaker 9: would get emails from friends, did you guys consider this?
- 11:31Speaker 1: You know, what about this? So we have an issue
- 11:32Speaker 1: with this? So those kinds of things.
- 11:38Speaker 9: That really helped us sort of fine tune some of
- 11:41Speaker 9: the drugs that were already on there, and then again
- 11:45Speaker 9: got our group together again. We added a few more
- 11:47Speaker 9: people so that we could have some more specialists, especially
- 11:50Speaker 9: I think it was really good to add somebody in
- 11:52Speaker 9: the psychiatry community because there was so much debate with
- 11:56Speaker 9: those medications, So adding some more specialists helped us.
- 12:00Speaker 7: Well, yeah, I'll say we did have a one month.
- 12:05Speaker 8: Period where the PPA membership we had public input.
- 12:09Speaker 7: This was kind of just before COVID hit, honestly, and
- 12:16Speaker 7: then our publication came out in early twenty twenty, and
- 12:21Speaker 7: I think with the second iteration we've had much more response. Right, So,
- 12:27Speaker 7: the first edition's been out there, it was kind of
- 12:30Speaker 7: launched under COVID, but the second edition is coming out now.
- 12:34Speaker 7: And now we'll say, we just submitted the Galilees today,
- 12:37Speaker 7: Rachel to the journal. So this one morning, the final
- 12:42Speaker 7: Gallalley proof was submitted.
- 12:45Speaker 4: Well, first, congratulations on the publication of that. I know
- 12:49Speaker 4: this is a labor of love that PPA has gotten behind,
- 12:54Speaker 4: and also you and many of your other colleagues have
- 12:57Speaker 4: along the process, and we're very grateful for it. As
- 13:00Speaker 4: fellow pediatric pharmacists. So let's dive into some of the
- 13:04Speaker 4: nitty gritty of the second edition, can we sure?
- 13:07Speaker 6: Okay, let's do it. Okay, So what do.
- 13:11Speaker 4: You think are some of the most significant additions or
- 13:14Speaker 4: maybe removals in the second edition. I had the privilege
- 13:17Speaker 4: of sitting in on your roundtable at the PPA meeting
- 13:20Speaker 4: out in Portland, Oregon and was super enlightened by it.
- 13:22Speaker 4: So I'd love to maybe rehash some of those to
- 13:25Speaker 4: our listeners. So Dave, they actually, let's do this. Rachel,
- 13:29Speaker 4: can you go first and maybe give us a couple
- 13:31Speaker 4: examples and then Dave can do the same.
- 13:34Speaker 9: Sure, So we'll talk about my favorite. Dave knows what
- 13:37Speaker 9: my favorite is. Montal lucast Monte Lucas is so difficult.
- 13:42Speaker 9: We went back and forth so much with it. Of course,
- 13:46Speaker 9: the big question with Monto Lucas is about the neuropsychiatric reactions,
- 13:51Speaker 9: specifically spleep sleep disturbances is what we landed on. And
- 13:56Speaker 9: the issue is this really sort of came out and
- 14:00Speaker 9: the last few years. It was one of the newer
- 14:01Speaker 9: things that we considered, and there's an FDA warning. But
- 14:06Speaker 9: the issue in terms of whether to include it on
- 14:08Speaker 9: the kids list or not, is if it's different than adults,
- 14:11Speaker 9: because remember, that's what makes the drugs and the kids
- 14:14Speaker 9: list unique, is that these are ADRs that specifically happen
- 14:18Speaker 9: more often in kids than adults, because we know these
- 14:21Speaker 9: reactions occur in both kids and adults. So we were
- 14:25Speaker 9: trying to peace out, well, is there any particular reaction
- 14:31Speaker 9: that was more common in kids, because again we have
- 14:34Speaker 9: adults that have these issues. So and the literature was
- 14:38Speaker 9: kind of back and forth, but at the end of
- 14:40Speaker 9: the day we kind of landed on the sleep disorder's
- 14:44Speaker 9: part does seem to have some clear evidence, at least
- 14:46Speaker 9: from what's out there now, that that is more common
- 14:49Speaker 9: in kids than adults.
- 14:52Speaker 1: And also, we.
- 14:52Speaker 9: Always kind of think about its efficacy because if this
- 14:56Speaker 9: is a drug where it's the only drug that you
- 14:57Speaker 9: can use for that disease state, then maybe the benefits,
- 15:01Speaker 9: you know, outweigh the risk. But in this case it's
- 15:05Speaker 9: not true, because of course, we have much better drugs
- 15:07Speaker 9: that we can use for asthma and other options for
- 15:10Speaker 9: allergies as well. So that's why that one was that
- 15:13Speaker 9: was a tough one that we went back and forth
- 15:15Speaker 9: on a lot.
- 15:18Speaker 1: The other one.
- 15:18Speaker 9: That's sort of my favorite is you know, ethanol, and
- 15:22Speaker 9: there's nothing really different about ethanol there, except that we
- 15:27Speaker 9: have some more data about ethanol's use. I actually had
- 15:30Speaker 9: one of my pharmacy students look at and calculate the
- 15:34Speaker 9: blood alcohol levels that kids would get by taking some
- 15:37Speaker 9: of the common medications. So we just did you know,
- 15:40Speaker 9: simple math based on usual doses for different weight ranges
- 15:45Speaker 9: and just showing you know, the blood alcohol levels that
- 15:48Speaker 9: would result. So we just had a little more data
- 15:51Speaker 9: in there. And that's an example too of where we're
- 15:53Speaker 9: hoping that things that are in the Kids list will
- 15:55Speaker 9: sort of inspire these kinds of projects so that we
- 15:58Speaker 9: can know more about what we're giving to kids.
- 16:02Speaker 1: By what your favorites were.
- 16:04Speaker 7: Oh, I thought you would start with that, but I
- 16:07Speaker 7: started with the other one, the loucast. Yeah, I've got
- 16:10Speaker 7: a couple of So tetracyclines are growing, you'll notice that
- 16:15Speaker 7: in this edition. So in the first we just had
- 16:18Speaker 7: a tetracycling and the mechl cycling I think. And so
- 16:21Speaker 7: now we're adding it as a class and we're able
- 16:24Speaker 7: to do that because some additional actually, you know, some
- 16:28Speaker 7: additional publications were came out from the time we published
- 16:34Speaker 7: the first time and the second time, so that allowed
- 16:38Speaker 7: us to open up the class and take another critical.
- 16:40Speaker 8: Look at it.
- 16:41Speaker 7: And so you'll find every tetracyclinge UH in the you know,
- 16:45Speaker 7: in the tetracycling classes in the list, with the exception
- 16:50Speaker 7: of doxy cycling. So you'll notice that one difference. And
- 16:54Speaker 7: really the tetracycling class we we we looked at the
- 16:58Speaker 7: level of evidence and you'll see that in the list,
- 17:01Speaker 7: the level of evidence on tooth discoloration mainly UH and
- 17:06Speaker 7: some have very you know.
- 17:08Speaker 8: Fairly robust data, like tetracycling itself.
- 17:11Speaker 7: Some have more limited data, and then some couple are
- 17:14Speaker 7: just package insert data. But we think, you know, we
- 17:17Speaker 7: think it's a class effect in that case. But with
- 17:20Speaker 7: doxy cycling, the medication has been out there for a
- 17:24Speaker 7: while and we just haven't seen a lot of tooth
- 17:26Speaker 7: discoloration with doxy and so right now we feel comfortable
- 17:31Speaker 7: leaving it off the list and allowing its use for
- 17:35Speaker 7: any time where it's a first line drug where where
- 17:40Speaker 7: other medications aren't more you know, superior, So doxy cycling
- 17:45Speaker 7: for up to twenty one days wherever it's recommended is okay,
- 17:52Speaker 7: let's see what another big change we had, we're the antipsychotics.
- 17:58Speaker 8: With the first edition, we had a lot of debate
- 18:00Speaker 8: around whether or.
- 18:02Speaker 7: Not we were going to fully break out the second
- 18:06Speaker 7: generation as psychotics and the metabolic effects. I remember there
- 18:11Speaker 7: was there was a lot of conversation around that. This
- 18:14Speaker 7: time we definitely broke it out the whole second generation
- 18:19Speaker 7: classes in the kids list. The first generations there as
- 18:22Speaker 7: well with the cute dys tonic reactions that we all
- 18:26Speaker 7: know about, but the second class is in there. We
- 18:28Speaker 7: have I think we have more robust data and Rachel,
- 18:31Speaker 7: you know, correct me if I'm wrong, but I think
- 18:33Speaker 7: we have more robust data around the metabolic effects a
- 18:35Speaker 7: lanzepine leading the charge there, and then we were able
- 18:39Speaker 7: to show which ones have greater risk metabolic risk and
- 18:44Speaker 7: which have lesser. So you'll see that big change in
- 18:48Speaker 7: there as well as a class.
- 18:53Speaker 9: The other thing that we tried to clarify was how
- 18:56Speaker 9: we defined age. So age is define so many different
- 19:01Speaker 9: ways in different places.
- 19:02Speaker 6: You know.
- 19:03Speaker 9: I think example, an infant we usually say is twelve
- 19:06Speaker 9: months and under, but the FDA says it's two years
- 19:08Speaker 9: and under. So you know, that kind of left us
- 19:12Speaker 9: scratching our heads a lot. So we decided to sort
- 19:14Speaker 9: of just I don't know, like not define it and
- 19:17Speaker 9: basically just say the age for each particular drug, so
- 19:20Speaker 9: that it was more clear and we stopped trying to
- 19:23Speaker 9: define it and lump kids into different groups.
- 19:28Speaker 6: I think.
- 19:30Speaker 5: There'll go ahead, go ahead, just on the topic of age.
- 19:33Speaker 5: I think one thing that's really interesting after COVID is
- 19:36Speaker 5: how we have so many larger children and we have
- 19:41Speaker 5: smaller adults. So like factoring in like age and weight,
- 19:45Speaker 5: I feel like is really important. So I guess, like
- 19:47Speaker 5: for the Kids List, did you look at age only
- 19:50Speaker 5: or were there weight cut offs as well? Like what
- 19:52Speaker 5: a weight of forty five kilos disqualify a kid from
- 19:56Speaker 5: the Kids List?
- 20:00Speaker 8: No, weight did not do it.
- 20:03Speaker 7: Where weight comes into play is in some of the recommendations.
- 20:08Speaker 7: We have a dose limits, so milligram per kilo, but
- 20:13Speaker 7: weight itself wasn't a cut off we did. I didn't
- 20:17Speaker 7: see anything in the literature showing that weight had an
- 20:21Speaker 7: independent effect on whether an eight R was greater or lesser.
- 20:28Speaker 8: I don't know.
- 20:28Speaker 7: If if if that's what your question is, it was
- 20:32Speaker 7: it was mainly based on age looking at it development,
- 20:36Speaker 7: I will add you know, there were there were a
- 20:38Speaker 7: number of other changes that we had in the list
- 20:41Speaker 7: we support. We've summarized them in the supplemental material. You
- 20:45Speaker 7: can read it and find all the little details about
- 20:49Speaker 7: what we did.
- 20:49Speaker 8: But we were removed.
- 20:51Speaker 7: I think it looks like five medications because they are
- 20:54Speaker 7: no longer manufactured in the United States.
- 20:58Speaker 8: And that's one thing that.
- 20:59Speaker 7: You need to keep into consideration is this is this
- 21:02Speaker 7: is a list of medications for drugs that are labeled
- 21:06Speaker 7: for use in the United States only, and other countries
- 21:09Speaker 7: may have them, but they won't be on our list
- 21:12Speaker 7: if they're not produced and labeled for use in the
- 21:16Speaker 7: United States. So we lost hexachlorophine and dinevereer lending and
- 21:22Speaker 7: paragoric I know, all fast movers, but they were all
- 21:26Speaker 7: removed because they're no longer available in the US, but
- 21:28Speaker 7: they may still be available in other countries.
- 21:33Speaker 4: I think that's a super helpful tidbit, because again I
- 21:36Speaker 4: think the Kids list has gotten international attention because it's
- 21:40Speaker 4: really the only list that's similar to the Beers criteria
- 21:44Speaker 4: that gives us some more guidance that we can point
- 21:47Speaker 4: back to as clinicians. So that's a really important thing,
- 21:51Speaker 4: and it kind of leads to this next question. How
- 21:54Speaker 4: do you envision pediatric pharmacists and other providers using the
- 21:57Speaker 4: Kids List in their daily practice? And here let me
- 22:01Speaker 4: give you some context. These are potentially inappropriate medications. Correct,
- 22:06Speaker 4: These are not never used, and so there requires clinical
- 22:10Speaker 4: judgment to determine well for this patient the benefits outweigh
- 22:15Speaker 4: the risks. And so what are some of those practical
- 22:18Speaker 4: ways in which you would suggest pharmacists use the Kids
- 22:22Speaker 4: List in their daily practice.
- 22:25Speaker 9: I think number one is to just be aware of it,
- 22:28Speaker 9: know that it exists as a resource, and that it
- 22:31Speaker 9: has good references, you know. I think that's one thing
- 22:33Speaker 9: we're very proud of, is the references that we've used,
- 22:36Speaker 9: and we've sort of told everybody this is where we
- 22:39Speaker 9: made like, this is the information that we use to
- 22:41Speaker 9: make our decision. And so if you need to use
- 22:43Speaker 9: it and you want to look at that to make
- 22:45Speaker 9: your own clinical decision, then you know, go ahead. And
- 22:49Speaker 9: then I think the next big thing is working it
- 22:51Speaker 9: into EMRs right as warnings. So but like you said,
- 22:54Speaker 9: this is not a list that do not use. This
- 22:57Speaker 9: is we're telling you about the risks and you need
- 23:01Speaker 9: to take your clinical situation into account.
- 23:04Speaker 7: It's very important the list should be punitive. It should
- 23:09Speaker 7: be for like quality assurance and general advice. Nothing in
- 23:15Speaker 7: here is a concrete yes or no. So everything in
- 23:20Speaker 7: clinical practice must be judged with the benefits and the
- 23:24Speaker 7: risks in mind. And a lot of the medications on
- 23:26Speaker 7: this list, if you look at them, they may be
- 23:30Speaker 7: perfectly fine for a five year old, but not fine
- 23:33Speaker 7: for you know, a very low birthwright infant. Okay, So
- 23:38Speaker 7: just because it's on the list doesn't mean that it's
- 23:40Speaker 7: inappropriate for all age groups or patients in the pediatric spectrum.
- 23:45Speaker 9: And the other thing to consider is even if it's
- 23:47Speaker 9: not on the list, that doesn't mean it is okay,
- 23:50Speaker 9: you know what I'm saying. It just means we didn't
- 23:52Speaker 9: have the information. Dave, you're gonna last laugh.
- 23:57Speaker 1: Last week I had a two year old who had.
- 23:59Speaker 9: Been for cyclamine, and I'm like, what, so looking at
- 24:04Speaker 9: the kids list, it's only do not use for we
- 24:07Speaker 9: have six months, is what we put.
- 24:09Speaker 1: But like, that's one where I was not comfortable with
- 24:12Speaker 1: this two year old. There was no reason for him
- 24:14Speaker 1: to be getting it.
- 24:15Speaker 9: I think it might have been I don't know, some
- 24:18Speaker 9: resident like a family Medicine resident or something like that
- 24:21Speaker 9: who was used to prescribing for adults. So that's an
- 24:23Speaker 9: example where that wasn't really on the kids list, but
- 24:26Speaker 9: not appropriate.
- 24:28Speaker 7: And I'll add I think we looked at the quality
- 24:31Speaker 7: of evidence certainly from high to very low, and we
- 24:34Speaker 7: included a very low level of evidence in peedes because
- 24:37Speaker 7: because there is very low qualities of evidence, unlike the
- 24:43Speaker 7: Beers criteria, which they have a little bit better evidence
- 24:47Speaker 7: than the older adults, in kids, we have such limited
- 24:50Speaker 7: data that we allowed a very low level of evidence
- 24:53Speaker 7: like just a package insert for example.
- 24:56Speaker 8: So you have to take that into consideration.
- 24:59Speaker 7: It's very very possible that, you know, evolving evidence will
- 25:04Speaker 7: change our recommendations on.
- 25:06Speaker 8: The list, and the list is it's not static.
- 25:09Speaker 7: It is something that does change over time, and it
- 25:12Speaker 7: is a bit evolving.
- 25:15Speaker 5: On the topic of things evolving, I'm just kind of
- 25:17Speaker 5: in this mindset of like you then it should be
- 25:20Speaker 5: integrated into EHRs. Is there anything out there or is
- 25:24Speaker 5: there anything in the works, like any sort of API
- 25:26Speaker 5: to get it into EHRs.
- 25:29Speaker 9: I'm not aware of anything, but I know that some
- 25:32Speaker 9: drug databases like lexicomp have picked it up and included it.
- 25:37Speaker 9: So I think that's going to be an evolving thing,
- 25:39Speaker 9: and I think it can also be done, you know,
- 25:41Speaker 9: on a hospital level. I also to another thing that
- 25:45Speaker 9: pharmacists can do to include it in their practice is
- 25:48Speaker 9: just sort of look at their formulary, right and look
- 25:51Speaker 9: and see what they've got. Like for example, at my hospital,
- 25:53Speaker 9: for our liquid benadryl, we were carrying the one that
- 25:55Speaker 9: had alcohol, so we got rid of it and we
- 25:58Speaker 9: subbed it out for the alcohol free one, you know,
- 26:00Speaker 9: just a simple example, or like tile and all with coding.
- 26:04Speaker 9: I think I tried to get rid of it ten
- 26:06Speaker 9: years ago, but there were still some adults who were
- 26:08Speaker 9: using it. But we tried again in the last year
- 26:11Speaker 9: or so and the adults had stopped using it too,
- 26:13Speaker 9: so we were finally able to just get it off formulary.
- 26:17Speaker 9: So that's just something just looking individually at at your formulary.
- 26:22Speaker 5: I feel like there's a lot of men safety projects
- 26:25Speaker 5: that can be like I guess for residents listening, this
- 26:28Speaker 5: is a great idea, like use this for your residency
- 26:31Speaker 5: project this year. This is a great like QI and
- 26:33Speaker 5: it's brand new literature. Hits all out there, So when
- 26:37Speaker 5: and where will the second edition of the Kids List
- 26:39Speaker 5: be published.
- 26:42Speaker 8: It'll be published very soon.
- 26:43Speaker 7: So as I mentioned earlier, it was just we just
- 26:47Speaker 7: submitted the galleys, the final galley proof this morning, so
- 26:52Speaker 7: June twenty third, it is in to the publisher, and
- 26:56Speaker 7: just as soon as those changes get made to the
- 27:00Speaker 7: original document, it's going to be up on the JPPT
- 27:02Speaker 7: website as an early publication, even before the next edition
- 27:08Speaker 7: comes out, So before the fourth edition of JPPT or
- 27:12Speaker 7: the edition, this will be up on the website. So
- 27:15Speaker 7: I'd be looking for it fairly soon. I would say,
- 27:18Speaker 7: I don't know, crossing my fingers next couple of weeks.
- 27:21Speaker 6: Oh that's great.
- 27:22Speaker 4: So this has been infinitely helpful for me, not only
- 27:25Speaker 4: in clinical practice, but I'm an educator just like Rachel.
- 27:28Speaker 4: I'm in the classroom with kids, helping them to be
- 27:30Speaker 4: ready to take care of pediatrics. I just called my
- 27:34Speaker 4: students kids. They're adults, okay. But one of the things
- 27:39Speaker 4: that I've done which has been a blast is when
- 27:41Speaker 4: I'm teaching all of our students in their year about pediatrics,
- 27:45Speaker 4: we actually do a kids a scavenger hunt, but it's
- 27:48Speaker 4: in the clinical context of a mini case where some
- 27:51Speaker 4: of them they may find information, but they then have
- 27:55Speaker 4: to go and decide, well, but is this the only
- 27:57Speaker 4: drug that might work for this patient for X y reason?
- 28:01Speaker 4: And it has been a blast, So Rachel, I would
- 28:04Speaker 4: love to know. Are there any unique educational things that
- 28:08Speaker 4: you've done with the Kids List at your own practice?
- 28:11Speaker 9: No, but I love that, and I might try incorporating that.
- 28:16Speaker 1: For me.
- 28:17Speaker 9: Like at at Rutgers, we've just tried to incorporate it
- 28:20Speaker 9: into our you know, Piet's classes, our therapeutics, just so
- 28:25Speaker 9: that again, students are aware of its existence. At my hospital. Again,
- 28:29Speaker 9: I've been trying to do the things I said before.
- 28:31Speaker 9: Going through our formulary, I gave a grand rounds. You
- 28:35Speaker 9: wouldn't believe how many older physicians were so upset that
- 28:39Speaker 9: aspirin didn't get a bigger warning, because you know, that
- 28:43Speaker 9: one was always that was very controversial the first time
- 28:45Speaker 9: it came around. But yeah, but no, I love the
- 28:48Speaker 9: idea of the scavenger hunt. That's a great one.
- 28:50Speaker 7: Along with that, Rachel, I would say, you run into
- 28:54Speaker 7: very unexpected interesting thelements when you're trying to roll out
- 28:58Speaker 7: the kids List and incorporate it into your EHR. Like
- 29:02Speaker 7: I ran into a little problem with sodium phosphate solution,
- 29:05Speaker 7: like you know, hyperphosphatemia and renal dysfunction in kids lessen too,
- 29:11Speaker 7: I think it is. Yeah, And I ran into a
- 29:14Speaker 7: couple of er docs that were just they had to
- 29:17Speaker 7: have it, you know, and it's interesting. You don't expect
- 29:21Speaker 7: you're going to run into a problem and then then
- 29:24Speaker 7: you run into something and have a nice conversation about that.
- 29:28Speaker 4: Yep.
- 29:30Speaker 5: Just on the same note of the scavengerhead. I think
- 29:32Speaker 5: one of the most fun educational activities I did for
- 29:34Speaker 5: my residence way back when was doing an escape room.
- 29:39Speaker 5: So it was just in a conference room and I
- 29:41Speaker 5: ended up hiding lots of things, so they had to
- 29:44Speaker 5: answer all the drug questions. I remembered one of the
- 29:47Speaker 5: questions was like which medication causes your CO two to drop?
- 29:52Speaker 5: And then they had to find the total MAX bottle,
- 29:54Speaker 5: So I hit a total Max bottle like somewhere in
- 29:56Speaker 5: the room. So of having the kids list medications hidden
- 29:59Speaker 5: somewhere in a common and room would be fun for
- 30:01Speaker 5: them to identify.
- 30:03Speaker 1: I love it.
- 30:04Speaker 4: Yeah, for educators out there, lots of creative things, but
- 30:07Speaker 4: again it's more about awareness and exposure, right.
- 30:10Speaker 6: This is a tool just like, we have so.
- 30:12Speaker 4: Many other clinical tools in our armamentarium to take care
- 30:15Speaker 4: of kids, but it's a significant one where we just
- 30:18Speaker 4: have this catalog of questions for different drugs that remind
- 30:23Speaker 4: us to think critically, and I think the Kids List
- 30:25Speaker 4: does that fantastically. I want to transition now again, the
- 30:30Speaker 4: second edition is an amazing thing. But if I know you,
- 30:35Speaker 4: Rachel and Dave, you're probably thinking forward even more, right,
- 30:38Speaker 4: So what are your hopes and dreams for the future
- 30:42Speaker 4: of the Kids List? And maybe I can ask a
- 30:44Speaker 4: specific example and you can answer broadly, But for example,
- 30:48Speaker 4: has pharmacogenomic data been discussed as being added to some
- 30:53Speaker 4: of the descriptions of the drugs where that's pertinent data
- 30:57Speaker 4: on whether you should should not use a drug, modify
- 30:59Speaker 4: a dose, et cetera. Or is that beyond the scope
- 31:02Speaker 4: of what you see for the Kids List?
- 31:04Speaker 1: Well, I think we incorporated it into coding, right.
- 31:07Speaker 9: Basically it all yeah, yeah, because we know places like
- 31:12Speaker 9: Saint Jude, you know, do that the kind of screening routinely.
- 31:15Speaker 9: So if they have that tool and that information, then
- 31:19Speaker 9: we don't want to block them or from using it.
- 31:22Speaker 1: So I think that's appropriate. But to answer your earlier
- 31:25Speaker 1: question in terms of hopes and dreams. My hopes and dreams.
- 31:28Speaker 9: Are to make sure this is available to all pharmacists,
- 31:32Speaker 9: especially in the community setting. We want to make sure
- 31:35Speaker 9: our community colleagues know about this and use.
- 31:38Speaker 1: It as a resource.
- 31:40Speaker 9: Just for an example, you know, here in New Jersey,
- 31:42Speaker 9: line disease is, you know, a pretty big problem, and
- 31:46Speaker 9: I know my infectious disease physicians, says she routinely gets
- 31:50Speaker 9: doxycycling calls from retail pharmacistsing it's inappropriate for kids because
- 31:55Speaker 9: that's what you were taught in school. So you know,
- 31:57Speaker 9: I get that, and that's probably what they're warning, you know,
- 32:00Speaker 9: system in their whatever HR system they use at that
- 32:04Speaker 9: particular store is. So we want to you know, roll
- 32:08Speaker 9: this out so that community pharmacists who take care of
- 32:12Speaker 9: a lot of kids, probably more than I do in
- 32:14Speaker 9: a single day, that they are aware of this resource.
- 32:19Speaker 7: And we need additional research. Just comparing the last the
- 32:24Speaker 7: first edition of the Kids List with the second edition,
- 32:26Speaker 7: you'll see numerous, numerous changes, and that just calls out
- 32:30Speaker 7: the need for more research, more publication. If you come
- 32:33Speaker 7: across a case, publish it. If you do a case,
- 32:37Speaker 7: a case series, or a cohort in your hospital, publish it.
- 32:41Speaker 7: We need that published. We don't go on feeling, we
- 32:45Speaker 7: go on the evidence based. So we do need more
- 32:48Speaker 7: publication with this. And so what we decided originally with
- 32:53Speaker 7: the first publication was that we would kind of look
- 32:55Speaker 7: at publishing it about every five years. And I don't
- 32:59Speaker 7: know how that's going to be, how that's going to
- 33:02Speaker 7: be borne out here. It's it's going to be five
- 33:05Speaker 7: years with this one. I think at the PPA board there,
- 33:09Speaker 7: I just looked at their h their their strategy, and
- 33:13Speaker 7: they were looking at updating the kids list every three
- 33:15Speaker 7: years in the in the in the strategy, So I
- 33:20Speaker 7: don't know, you know, that would be more of a
- 33:21Speaker 7: continuous thing because it takes so long to do the
- 33:24Speaker 7: date of mind and getting the people together and hashing
- 33:27Speaker 7: it out. We we've also talked about having a just
- 33:31Speaker 7: sort of a place on the website at p PA
- 33:34Speaker 7: where people can submit comments and it won't go to me.
- 33:38Speaker 7: I'm the corresponding author, so people can email me at home,
- 33:42Speaker 7: or they can email Rachel, or we can have a
- 33:44Speaker 7: nice place on the p PA website where people can
- 33:47Speaker 7: go and possibly in the future the document could be
- 33:51Speaker 7: more living Uh, it could. It could exist more on
- 33:53Speaker 7: the on the website, So that's something that we could
- 33:56Speaker 7: consider as well.
- 33:59Speaker 5: And like a little drop box like I found this
- 34:03Speaker 5: and that'll help people that even more. I'm thinking, like
- 34:06Speaker 5: I'm in this technology bubble right now where I'm thinking
- 34:10Speaker 5: of having that integrate with like the drug interaction checker
- 34:13Speaker 5: for like LEXI or clinical pharmacology where when you punch
- 34:16Speaker 5: in the drug interactions, and especially for the retail setting,
- 34:19Speaker 5: like if they were to put that into the system,
- 34:22Speaker 5: it would flag and be like, hey, this is on
- 34:24Speaker 5: the kids list.
- 34:29Speaker 4: So Dave and Rachel, how can we as pediatric pharmacists
- 34:33Speaker 4: be a part of getting the word out? I know
- 34:35Speaker 4: that was a big discussion at the PPA meeting. And
- 34:38Speaker 4: this is a is a pharmacist driven document, which I
- 34:42Speaker 4: think is super super cool. It's applicable to all pediatric
- 34:45Speaker 4: pharmacy practice, but it's pharmacists driven. I'm likeke the Beers criteria,
- 34:48Speaker 4: which does involve farm dees in it, and so I
- 34:51Speaker 4: don't want to mischaracterize that, but this is pharmacy driven,
- 34:54Speaker 4: and so we should be proud of it, not only
- 34:56Speaker 4: because of that, but because of the kind of value
- 35:00Speaker 4: brings as another tool in our ommitarium. So just to
- 35:04Speaker 4: go back and relate the question, how can we get
- 35:07Speaker 4: the word out about the Kids List?
- 35:10Speaker 9: I think educators teach it right, just like you're saying, justin,
- 35:14Speaker 9: I think that is where you start right, teaching the
- 35:17Speaker 9: new ones. And then we're doing our best with our
- 35:20Speaker 9: Dog and Pony Show to take it around. We're hoping,
- 35:24Speaker 9: you know, to partner with some other organizations so we
- 35:26Speaker 9: can present more on it.
- 35:28Speaker 7: Yeah, it'd be nice to get a little bit more
- 35:31Speaker 7: of our community colleagues, right, and our ambulatory colleagues find
- 35:36Speaker 7: ways to reach them through associations or societies. But yeah,
- 35:41Speaker 7: teach it, use it, bring it to practice, bring it
- 35:45Speaker 7: to P and T and incorporate that will get a
- 35:49Speaker 7: lot of buzz.
- 35:49Speaker 8: It'll get a lot of people talking.
- 35:51Speaker 7: So educating on it, researching on it, using it, referencing it.
- 35:57Speaker 8: I think we'll get the word out. Will take some time, but.
- 36:04Speaker 4: Well, we appreciate both of you coming on to the
- 36:07Speaker 4: podcast to give us a little bit of a taste
- 36:10Speaker 4: of the updates that are coming.
- 36:12Speaker 6: Are there any last things about the Kids List?
- 36:14Speaker 4: Do you want to make sure that our listeners are
- 36:16Speaker 4: left with any words of wisdom or last pieces that
- 36:19Speaker 4: you think are important with this update.
- 36:22Speaker 9: Just I think for me, I'm so grateful to all
- 36:24Speaker 9: the pharmacists who read our early editions, both the first
- 36:27Speaker 9: edition and the second edition, look through the table and
- 36:30Speaker 9: gave us comments. It's a better document for it, and
- 36:34Speaker 9: we just are really appreciative of that without question.
- 36:37Speaker 7: And I would add the additional subspecialists on our on
- 36:42Speaker 7: our team have been invaluable. They have insight, they walk
- 36:47Speaker 7: in places that I don't normally walk, and so they've
- 36:49Speaker 7: brought a lot of value to the final product. So
- 36:53Speaker 7: it's a lot better. But you know, it's something that's
- 36:56Speaker 7: just going to keep changing as we get more information.
- 36:59Speaker 8: So there were a.
- 37:00Speaker 7: Lot of changes between the first and second Sorry about that,
- 37:04Speaker 7: but as the data changes, we have to move with it.
- 37:10Speaker 4: Well, if we're practicing evidence based medicine, we've got to
- 37:13Speaker 4: do that right. We've got to be willing to pivot
- 37:15Speaker 4: and sometimes even call things that work standard of care
- 37:19Speaker 4: no longer the standard of care when we need to.
- 37:22Speaker 4: So that's part of having that clinical humility, if you will,
- 37:26Speaker 4: right of understanding that sometimes we didn't have the data
- 37:30Speaker 4: we wished we did, and when it changes, we follow it,
- 37:32Speaker 4: so we appreciate you guys helping us do that again.
- 37:35Speaker 4: Thank you so much, Rachel and Dave for joining us
- 37:37Speaker 4: on the podcast. Mary.
- 37:39Speaker 6: Always great to talk.
- 37:40Speaker 4: With you, and we look forward to seeing you on
- 37:43Speaker 4: thet on this next podcast episode of The Pediatric Pharmacy Review.
- 37:49Speaker 5: Thanks, thank you, every good tea.
- 37:52Speaker 8: Thanks so much.
- 37:53Speaker 6: Yeah, thanks guys, We appreciate you so greatly. Students.
- 37:56Speaker 4: Hopefully this is a great learning experience. If you haven't
- 37:59Speaker 4: heard of the kids list, my apologies. Give me your faculty,
- 38:02Speaker 4: your peed's faculty members name, and I'll email them and.
- 38:05Speaker 6: Suggest that they look at it for you.
- 38:07Speaker 4: So well.
- 38:08Speaker 1: Joshua, I know, is one of ours.
- 38:10Speaker 6: So oh great. Okay, so he's covering. Good job. Sounds good. Well,
- 38:15Speaker 6: thanks again, guys.
- 38:16Speaker 1: All right, thank you guys, thank you, thanks for having
- 38:19Speaker 1: us a great week.
- 38:20Speaker 3: That's all for today's episode. Thanks for listening, and remember
- 38:24Speaker 3: to subscribe on Apple Podcast and leave us a review.