Latest / The BioHub - by Avetix / Episode 115 - Simeon George - CEO & Co-Founder of SR One Capital Management
Transcript
- 0:06So welcome back to the episode of the Biohub.
- 0:08Today we're thrilled to welcome on Simeon George, who's the CEO,
- 0:12Co founder and Managing Partner of SR1SR1.
- 0:16Simeon leads one of the industry's most respected
- 0:18biotech investment teams, partnering with founders who aim
- 0:21not just to treat disease, but to change the course of it
- 0:24entirely. Simeon's backed marquee
- 0:26companies such as CRISPR Therapeutics, Principia
- 0:30Biopharma, Turning Point Therapeutics and Co founded
- 0:33Encarta Therapeutics and Arcelix, companies that are
- 0:36pushing the boundaries of patient medicine.
- 0:39So join us today. Simeon will give us an insight
- 0:42into SR1 and how the firm has evolved, SR1's approach and how
- 0:47much support is given to companies upon investment.
- 0:50So Simeon, thanks so much for coming on.
- 0:51How are you? Yeah, I'm well, thanks.
- 0:53It's good to see you. Thank you for this opportunity.
- 0:55Yeah, look, it's a pleasure. So look, let's just start with a
- 0:58little bit about your journey through the field.
- 1:00So you've moved from neuroscience to medicine to
- 1:03strategy, and now it's a biotech venture.
- 1:06Can you walk us through that journey and ultimately what
- 1:10pulled you towards building companies rather than practicing
- 1:13medicine? Yeah, no, you know, it's
- 1:15interesting. It always looks when you read
- 1:18the bio, it looks like it's a linear story and it all was
- 1:20planned out and I had this idea for what I wanted to do.
- 1:23And in general, like, I think probably what has drawn me to
- 1:27the work that I do is I like uncertainty.
- 1:29I like working on things where it's unclear even what I'm going
- 1:32to be doing that day, let alone months or years or decades.
- 1:37And so medicine for me was always sort of the calling from
- 1:40the time I was my earliest memories.
- 1:42I've always been fascinated by medicine.
- 1:44My parents were both physicians. And I always have the sense of
- 1:47like problem solving in a moment in time that is most crucial to
- 1:52someone's life, their family's life, etcetera.
- 1:56So that was the draw to medicine.
- 1:58You know, I'd say I was, I guess, fortunate enough to
- 2:01realize early on in that medical training that I wanted to kind
- 2:04of mix things up. I wanted to figure out how to
- 2:06use that training, but do it in a way that was less defined than
- 2:10just a pure clinical path. And that led me to to do a
- 2:15concurrent MBA alongside my medical degree.
- 2:18And that led me to work in in finance and consulting and
- 2:21investing in start-ups. But it was sort of one of these
- 2:25things where one door opened up another.
- 2:27There wasn't like a plan like I needed to get here.
- 2:29I needed to be in venture. It was always just trying to
- 2:32make a decision at that moment in time that I thought was the
- 2:35most interesting where I would learn something, where I had the
- 2:38sense that the quality of the people was going to allow me to
- 2:41learn and develop. And that's frankly where I am
- 2:46today. And that's if you were to ask me
- 2:47the next 3571015 years, I would give you a similar answer.
- 2:51Like I'm just going to continue to follow intuition, have this
- 2:54focus on clinical like patient impact and now being able to do
- 2:59it at a scale that is truly just, you know, sometimes you
- 3:03have to pinch yourselves to think about the way some of
- 3:05these medicines are going to transform patients lives.
- 3:08And the beauty of the work that we do is as you know, when we do
- 3:10that, we can have this tremendous financial outcomes
- 3:13and success. So it's just like, I can't think
- 3:15of anything more rewarding that I'm able to spend my time on.
- 3:20Nice. And just to delve into SR1 and
- 3:24how the firm, I guess from your perspective, how do you think
- 3:27the firm has evolved from its origins to guess, so I guess
- 3:30where it is now? Yeah.
- 3:32I mean, it's an incredible journey.
- 3:33I mean, I feel like there should be a book or a case study done
- 3:36on SR1I mean, it was started initially as the venture arm of
- 3:39Smith, Kline and French, I think in the mid 1980s.
- 3:44So it's one of the oldest corporate venture capital arms
- 3:47set up at a time when biotech was just emerging as a new
- 3:50industry. And and you know, the firm under
- 3:55sort of that GSK umbrella lasted for 35 years.
- 4:00And it did so first and foremost because it generated outsize
- 4:04performance. So it was a profit Center for
- 4:07the for the parent company and it also shone a light on
- 4:10obviously all the incredible innovation that was happening
- 4:13externally. And so I joined in the late
- 4:162000s and was there for over a decade, really learning the
- 4:20craft of investing. And then in 2020, you know, I, I
- 4:24led the spin out and the creation of the independent
- 4:27fund. And so we are very much, you
- 4:30know, independent. We're founder LED, you know, as
- 4:33you mentioned my bio, I've been involved in sort of helping to
- 4:36craft the new fund, the new set up.
- 4:38We're incredibly proud of the history of SRO One and the
- 4:42support that GSK gave us, call it during that Chapter 1.
- 4:46Chapter 2 was really the spin out, creating this independent
- 4:49business, setting it up with a foundation both across capital
- 4:53from, you know, new investors as well as building the team.
- 4:57And now this next chapter, I would say is really about taking
- 5:00SR1 and taking it to the next level and hopefully creating a
- 5:03firm, a truly elite firm that is backing world class science
- 5:08entrepreneurs and founders. And again, the playbook of
- 5:11science to medicine, really transforming the way we think
- 5:13about human health from the clinical side is, is really the
- 5:18mission that we're on. Nice.
- 5:20And the latest fund that SR1 closed was $600 million in 2023.
- 5:26Can you share the vision behind it and where you see the biggest
- 5:29opportunities where this capital is meant to or maybe even some
- 5:33highlights of companies that you have invested in since that
- 5:36latest fund as well? Yeah.
- 5:38So we are, I mean we've raised, we manage over $2 billion now
- 5:42across 2 venture funds and a growth fund and we are an end to
- 5:46end platform. So if you know like when
- 5:47investors ask me like what what makes us different or unique.
- 5:50So 1 is that DNA of pharma heritage and we'll talk about
- 5:54why that's so important. The second is we are a platform
- 5:57that is end to end. So we are doing everything from
- 5:59early stage company creation. You mentioned our Selex and
- 6:02Encarta. Those are companies that we
- 6:04started from a piece of paper with incredible founders
- 6:09alongside us. And then you know we're
- 6:11investing through that venture sort of entry point and again
- 6:16companies like CRISPR, Principia you mentioned are are good
- 6:19examples of that. And we have added a dimension
- 6:21now which is later stage investing both private and
- 6:24public to really take advantage of.
- 6:26You know, what has been a really challenging market environment
- 6:29for the last few years in biotech, which on the flip side
- 6:32has created in our, in our opinion, dislocation and an
- 6:35arbitrage in terms of being able to access high quality companies
- 6:40with product focus with proof points that we believe are truly
- 6:44valuable that the market isn't seeing yet.
- 6:46And so we've been able to invest in some of those later stage
- 6:49companies. So it is, it's an end to end
- 6:51platform. It's also transatlantic.
- 6:54So I'm sitting here today in London, my team is split between
- 6:57San Francisco and and London. So we are looking and sourcing
- 7:01ideas that are coming West Coast through the US East Coast, UK,
- 7:05Europe. And obviously now with
- 7:07everything that's happening in China, we've been quite active
- 7:09in terms of sourcing assets to put into our into our into our
- 7:13start-ups. So you know, it's an incredibly
- 7:16busy period and we've had some great, this year's been just an
- 7:21amazing year. You know, we've had a handful of
- 7:25partnerships, M&A events as well as public companies that have
- 7:29traded incredibly well. And so just to give you a sense,
- 7:33you know with eight RX, which is our RNA focus company out of San
- 7:38Diego that we've been involved in for the last five years, it
- 7:42truly is just a spectacular founder platform that is now in
- 7:46really the product development stage.
- 7:48So we have multiple clinical programs that are showing really
- 7:52a best in class profile. We have a deep research engine
- 7:58that we ended up actually partnering on with AbbVie and
- 8:03it's one of the largest research deals that's ever been concluded
- 8:07in the history of biotech and pharma. 335,000,000 upfront
- 8:11multi billion dollar milestone on the on the back of a research
- 8:15collaboration as an example through to things like
- 8:20Mineralis, which is from our last fund, which has a product
- 8:25that is now through phase 3A new medicine for hypertension for
- 8:29patients that aren't well controlled on the existing
- 8:32treatment paradigms. And so that's a company that
- 8:34we've been involved in pre IPO, through IPO, through follow ONS
- 8:38that is now, you know, I think trading at an all time high like
- 8:42a 4 billion plus company. So again, like through
- 8:45partnering through M&A, we've been able to really realize
- 8:48significant value. So we're excited about what
- 8:50we're doing, you know, but also acknowledging again, this is a
- 8:54very volatile, fickle environment.
- 8:57So you're only as good as your next deal, right?
- 8:58So you have to continue to hustle and and find ways to to
- 9:02identify the next ATRX, the next Mineralis and everything that
- 9:05we're doing. You, you mentioned then that
- 9:07obviously there's some of the team that are based in London,
- 9:10some of the team that are based in San Francisco.
- 9:12How does that sort of synergy with the team work given that
- 9:15you're in, what is it 8 hours apart?
- 9:17Does that work well managing different time zones?
- 9:20It's hard. I mean, there's no getting
- 9:22around it, you know, it's a hard.
- 9:23Ideally, we would all be sitting in one room together and, you
- 9:27know, storming and thinking through and making decisions.
- 9:31Again, we do see the benefit, as I mentioned, of having network
- 9:34access that is local, that allows us to take advantage of
- 9:38incredible science and start-ups that are in these different
- 9:42ecosystems. The challenge is how do you sort
- 9:44of meld? As for us, we lean heavily on
- 9:48teamwork, organizational design. We talked about one Team 1
- 9:51dream. And so you could be sitting here
- 9:53in London, but you're still very much plugged into what's
- 9:56happening in the Bay Area. The way that we work on sub
- 9:59teams, it's across geographies. So what that means practically
- 10:03is there's early mornings for the the West Coast team and
- 10:07there's late afternoons or evenings for the UK folks to try
- 10:10and find ways to cross talk. We're together a handful of
- 10:14times during the year. So you know, as we were talking
- 10:17about before we came on air, Jeffrey's next week, the
- 10:20investing team from the US will be here, JP Morgan, the team is
- 10:24together on the West Coast and then we have a couple of off
- 10:26sites during the year. So we find ways intentionally to
- 10:29be together, which is important. And then the last thing again,
- 10:34because we are end to end in terms of entry point, we do
- 10:37think it's an advantage to have those that are focused on early
- 10:40stage have a perspective coming from the late stage in terms of
- 10:45where the competition is, regulatory, pricing, all those
- 10:48things that you don't necessarily think about as
- 10:50intuitively if you're working on a start up, just being able to
- 10:53cross talk in both directions we think is an edge for us.
- 10:57So there is a method to the madness again of having this
- 11:01sort of eight hour split and it's working so far, but it
- 11:05takes, it's a practice, you have to lean into it.
- 11:08Otherwise it can easily get into like two different silos, which
- 11:11is not what we're about. How, how would you describe Sr.
- 11:141's investment approach? I think just before you
- 11:16mentioned that there's obviously some company creation, there's
- 11:19obviously some Series A, Series B.
- 11:21Should you just go into that a little bit further?
- 11:23And are there any particular therapeutic spaces where you
- 11:27find yourself particularly excited about at the moment?
- 11:29Like what areas are you seeing that I think are quite hot that
- 11:32are out there? I mean, so it's the pragmatic
- 11:35answer is again, given the flexibility of our platform, our
- 11:38entry points, we're looking for ways where Sr. 1's edge can
- 11:44really materialize. So edge through the network
- 11:47access, the founder entrepreneurs that we know that
- 11:49we think highly of or that we want to work with.
- 11:52So leveraging that access point to be able to identify great
- 11:57ways to invest and again, going across the spectrum like early
- 12:00through late. So that's one we, we spend quite
- 12:04a bit of time on what we call prepared mind.
- 12:07So really thinking about, you know, whether it's disease area
- 12:10modality, what are the scientific sort of breakthroughs
- 12:15that we think are ripe for really innovation in the context
- 12:20of startups and productization, right.
- 12:22And so we have that sort of map, if you will, head to toe.
- 12:25So we have a sense of where we want to play, what are the
- 12:27areas? And then I'd say there's a
- 12:30bucket that's in AI touched on this earlier sort of leaning
- 12:33into the pharma DNA. You know, we have been building
- 12:37incredible and deep ties across the board now large pharma, mid
- 12:41pharma to really understand the those stakeholders, those buyers
- 12:45of our product, if you will. And so we have a sense, you know
- 12:50of where they are, where they thinking, where do they want to
- 12:52go. So that's incredibly helpful.
- 12:54And then the last category is probably what I would call Yolo,
- 12:58which is like, it's not like you're planning it.
- 13:01It's just like you see something and you fall in love with the
- 13:03founder, you know, the science, the program.
- 13:07And you say, like, I have to do this deal, right?
- 13:09And so you're sort of putting all those forces together to
- 13:11create a portfolio of, call it, 20 companies and, and it works
- 13:17out. I mean, it's interesting that
- 13:18without necessarily engineering it, the portfolio reflects a
- 13:22bucket around early stage novel science platforms, a bucket
- 13:25around venture driven by founders, entrepreneurs that we
- 13:30want to work with, and a bucket around the late stage largely
- 13:33driven by products that we believe can be transformational
- 13:36medicines. And that's, you know, that's how
- 13:37we spend our time. Fine.
- 13:39And I know probably every VC is is different with this in terms
- 13:42of like once you invest in a company, you know you're going
- 13:45to be hands on or do you leave the company to it?
- 13:47What's SR1's approach to that? When you invest into a company,
- 13:51do you be pretty hands on as a firm?
- 13:54Do you have people that will will help out on an operating
- 13:56basis or do you leave the the sort of founders and management
- 14:00to it like how, how does that work from the from an investment
- 14:02side? Yeah.
- 14:03I mean, again, I'd say intentional is a word that I
- 14:06think about a lot and everything that we do.
- 14:08So it really is courses for courses, if you will.
- 14:12So it depends on what the company, the founders need, if
- 14:16we are, if we feel like there are ways that we can be helpful.
- 14:19And we do have these incredible and particular venture partners
- 14:23on my team, Chris Chai, Iqbal Mufti, I mentioned in particular
- 14:27that have deep experience when it comes to capital raising,
- 14:30both private and public or pharma engagement like those two
- 14:34areas obviously become critical for most startups.
- 14:37And so our portfolio companies and the executives lean heavily
- 14:40on those two individuals as the companies are evolving as an
- 14:43example, right? But we also don't want to be too
- 14:46prescriptive. Like, you know, if companies are
- 14:49well resourced to have a clear sense of how to execute on those
- 14:52aspects, we don't want to come in and then manage them, right?
- 14:56So we start with first principles like we are trying to
- 14:59create the most valuable company that we can, working alongside
- 15:03the founders. We're there to help the founder
- 15:05and entrepreneur realize their full potential.
- 15:08If we can be helpful beyond just the capital that we're
- 15:11providing, then we're all in and and we will do whatever we can.
- 15:14But we don't want to necessarily insert ourselves if that's not
- 15:18needed. And then lastly, I'd say, and
- 15:21I've seen it just frankly in the last week with some of our
- 15:23companies, we want to be the first call to our when, when
- 15:27something is going wrong, you know, when something's going
- 15:29right, obviously it's easy. But when things there's a
- 15:31challenge and invariably in every company there is, we want
- 15:35to be the first call that the founder entrepreneur is going to
- 15:37make, in part because we want to be there and seen as someone
- 15:40that is going to be objective, not necessarily just thinking
- 15:43about what does this mean for SR1, our fund.
- 15:47He's gonna problem solve. He's not gonna just criticize.
- 15:50He's going to find a way to hopefully work through this.
- 15:54And that's, you know, I feel like we, we shine in this
- 15:58category. Like if you were to talk to our
- 15:59founders entrepreneurs, I think you would hear this pretty
- 16:01consistently. We're there to help them and
- 16:03we're there to really our view is if we can align around, how
- 16:06do we create the most valuable company?
- 16:08Everything else takes care of itself.
- 16:10Just onto the market, like how, how are you seeing things that
- 16:12are it's obviously super volatile still.
- 16:15Are you seeing any changes in the market going into 2026?
- 16:18Do you have like a general perspective on on how I guess
- 16:22the the future of biotech looks just given how how difficult
- 16:25it's been over the past two or three?
- 16:27Years. I mean, listen, the last few
- 16:29months have for sure I'd say been more uplifting for the, the
- 16:34sector, right? If you just look at the indices,
- 16:36XPI is up, I don't know, 4050% there's been 20 plus billion
- 16:42worth of M and AI think I just saw an some news today around
- 16:46another exit potentially of Sedera.
- 16:50As I mentioned, we've had a handful of really important
- 16:52milestones. So there's things that are
- 16:54happening, right? The market is, is rewarding some
- 16:57of the, the ways that biotech is, is showing proof points.
- 17:01So that's important. Capital is getting recycled
- 17:03because of these liquidity events, follow ONS are happening
- 17:08for companies. Companies are raising large
- 17:10rounds, new funds are closing. So I think all of that is good.
- 17:16I mean, against what continues to be a really challenging or
- 17:19dynamic, I should say, market backdrop, you know, can just
- 17:23point to everything that's happening in the US on the
- 17:26regulatory side, pricing, tariffs, what's happening in
- 17:29China like this, You know, it's hard to imagine that the world
- 17:33that we are, the playbook that we're using today is going to
- 17:36look the same in 20-30 as an example, right?
- 17:38It just feels like there's so much that is moving pretty
- 17:41quickly. And so we just need to be, our
- 17:43job as venture capitalist is to live in the future.
- 17:46So we have to form a view and be courageous and sort of make
- 17:49some, make some investments and bets that sort of reflect where
- 17:54we think the the future is going to move towards.
- 17:56Yeah, I think what's been interesting I think from a
- 17:59recruiter that's on the other side of the fence and sees the
- 18:02market in some in terms of number of companies hiring and
- 18:04number of roles available. I think there's there's
- 18:06definitely been a shift. There's we're having a lot of
- 18:09conversations at the moment with private companies who are
- 18:12looking to go IPO next year. So I think that that window
- 18:15potentially could open up next year, which I think is exciting.
- 18:18And we're fortunate to have LB Pharmaceuticals and Map Light on
- 18:21the podcast recently as well. So hopefully there's there's
- 18:24optimism that that the IPO market will open up next year as
- 18:28well. I think that's we need that
- 18:31market to work right. We need companies to be able to
- 18:33continue to raise capital, lower their cost of capital.
- 18:37So that I think that's another proof point that we need to
- 18:40watch going into 26. As you said, there's been a few
- 18:43IPOs, but not many, right? I don't think we're going to get
- 18:46back to like where we were in 19/20/21, but there's probably a
- 18:50middle ground where we need to hit.
- 18:51Yeah, for sure. And just from your experience
- 18:55with SR1, what signals or tells you that biotech is ready for an
- 18:59acquisition versus being better positioned to grow
- 19:03independently? Like is there a point where you
- 19:05think, right, this is the time or how does that work from a
- 19:09venture perspective? I mean, it's really hard to be
- 19:11honest. Like I think, you know, I guess
- 19:14my view has always been you just have to continue to build.
- 19:17You have to give yourselves options, right?
- 19:19Ideally, you want to be in this incredible position where
- 19:22there's a route that says you can continue to remain
- 19:24independent, which means you likely need to be able to
- 19:27continue to raise capital to support development,
- 19:30commercialization of your products.
- 19:31Which means you likely need to go public at some point to
- 19:34continue to broaden out your shareholder base, lower your
- 19:38cost of capital. And if you're doing those things
- 19:41and if you're continuing to make technical progress as the
- 19:44medicine really starts to reveal itself and there's clarity
- 19:47around regulatory endpoints, what the commercial opportunity
- 19:51looks like, that's when you can start to engage meaningfully
- 19:55with strategics and hopefully create some level of scarcity
- 19:59around. The product, the company that
- 20:02can maybe turn into something that opens up the door for
- 20:06partnering with M&A. But it's hard.
- 20:08Like, you know, the adage is like great companies are bought,
- 20:12they're not sold, right. So I think you have to kind of
- 20:15live in a world where you you need to be able to control your
- 20:18destiny until someone comes and knocks on your door and gives
- 20:21you an offer and you can't refuse.
- 20:23Just on a more personal note, obviously biotech and venture
- 20:27can be intense, high pressure, stressful, etcetera.
- 20:31How do you sort of manage work life balance and and manage the
- 20:35demands of the field? Yeah, I mean, I don't think
- 20:39there's any easy way. So a couple of things, like
- 20:43practically, you know, I'm now spending more time in the UK,
- 20:46which means my mornings now I have more time to think, more
- 20:50time, you know, to drop my kids off at school as an example.
- 20:54Just sort of be present and trying to be intentional.
- 20:58Because again, when the West Coast comes online in the
- 21:00afternoons and it gets quite busy and I'm I'm in the office
- 21:03or in meetings, etcetera. So there's a way practically
- 21:05like I'm trying to manage at least my days.
- 21:10And then, yeah, I mean, again, I think it's just, you know, and
- 21:14when you're a founder, when you're building a business,
- 21:16whether it's an investment firm or start up the business, you
- 21:19have like you're sort of 24/7, I think wired to be thinking about
- 21:22it. So it's like finding ways to
- 21:24disconnect at least for some period.
- 21:26And you know, whether it's family, friends, exercise, all
- 21:30those things that, you know, we want to do, try and do those.
- 21:33And, and sometimes I get that mixed right.
- 21:35And sometimes I'm intentional and a lot of times I'm not.
- 21:38So it's a work in progress. Yeah, Finally, final question.
- 21:43We'll finish on. If you were to have dinner with
- 21:47any free people, past or present, who would you go from?
- 21:50Why? It doesn't necessarily need to
- 21:52be people in biotech. It could be someone from
- 21:55sporting world, entertainment world, wherever you want.
- 21:58But yeah, free people you'd like to have dinner with and why.
- 22:01Yeah, it's a good question. So I've been inspired by Vincent
- 22:07van Gogh for the longest time. I was an art history major in
- 22:10university and I just love his work and I love the story of Van
- 22:14Gogh. A struggling artist only sold
- 22:16one painting in his entire life, but obviously he just had a way
- 22:20to see things and do things that were just, again, truly
- 22:24transformational. So usually whenever I'm in a
- 22:26city, I will go to a museum that has a Van Gogh painting and I
- 22:29will take that in and get inspired by that.
- 22:31So to have dinner with him would be amazing.
- 22:36I would say, you know, the candidly, regardless of
- 22:39politics, I think someone like Azoran Mamdani is a pretty
- 22:43interesting figure. You know, for me, it's how do
- 22:46you go from like, no one knowing you having like less than 1%
- 22:50name recognition in January of this year to not only winning
- 22:54the mayoral race in New York, but doubling the vote, like
- 22:57literally increasing by twofold the number of people that came
- 23:01out to vote. And so just his marketing
- 23:04skills, his charisma, his ability to tell his story, I
- 23:08think for all of us, I think we can learn something from that.
- 23:11So I'd be interested to have a meal with him.
- 23:15And then lastly, who would, I mean Aretha Franklin?
- 23:24No other reason than I was last night again when I was trying to
- 23:28like unwind. Just it popped up on YouTube.
- 23:31This video of her. She was performing.
- 23:33It was some I think Presidential Medal of Honor or something.
- 23:36I think she was receiving, she was performing in front of a
- 23:40bunch of luminaries, including Obama, and she was like, this is
- 23:43late in her career and man, she just walked onto the stage and
- 23:47just owned it. And the voice was there.
- 23:49She playing the piano. At one point Obama was crying.
- 23:52Like it was like truly like inspirational moments.
- 23:56I again, like, I, I think just spending time with her, hearing
- 24:00her story, what she's lived through, I think would be also
- 24:03pretty inspiring. So those would be my 3.
- 24:06Nice. Yeah, we'll look 3 great answers
- 24:08there. And yeah, thanks for coming on
- 24:09and helping us out with this. I think what you, you're
- 24:11obviously building at SSR one is, is super impressive.
- 24:15Obviously a venture firm that I have been very familiar with and
- 24:18will continue to follow going forward.
- 24:20So yeah, congratulations on, on the work that you're doing and
- 24:23thanks for for helping us out with this.
- 24:24It was a it was a pleasure. Thank you.
- 24:26No, thanks for your time. Thanks for the questions.
- 24:28I enjoyed it. And yeah, hopefully look forward
- 24:29to seeing you in the future.