1003-The Cutaneous Wound Response Program in PDAC Malignancy
This research identifies a conserved genetic program called MP10 that drives the transition of benign pancreatic lesions into invasive pancreatic ductal adenocarcinoma (PDAC). Mirroring the process of cutaneous re-epithelialization used in skin wound healing, this program enables cancer cells to breach the basement membrane and infiltrate surrounding tissues. The transcription factor FOSL1 acts as a master regulator of this transition, while tumor suppressor genes normally serve as a critical checkpoint to keep these invasive cells in check. The study further reveals a wound-like feedback…
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