Blog: The Role of R-loops in Neuronal Aging
R-loops are structures that form when the nascent RNA hybridizes with the template DNA strand, displacing the non-template strand. Nascent RNA refers to the newly synthesized RNA molecule that is produced during the process of transcription. Transcription is the first step in gene expression where the information in a DNA sequence is used to create an RNA molecule. In addition to transcription, R-loops are involved in various biological processes, such as splicing, DNA repair and chromatin remodeling. However, when R-loop homeostasis is disrupted, they can also cause transcriptional…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.