1676-Hepatocytes Promote Pancreatic Cancer Liver Metastasis

Paper Talk · Oct 15, 2026 · 23m

Pancreatic ductal adenocarcinoma heavily relies on the liver microenvironment for survival when cancer cells lack the phosphoglycerate dehydrogenase enzyme required for de novo serine synthesis. To overcome this vulnerability, these exogenous serine-dependent tumor cells secrete CXCL5, which binds to CXCR2 on adjacent hepatocytes to trigger PI3K-AKT signaling. This activation results in the cytoplasmic sequestration of FOXO3A, relieving its transcriptional repression of PHGDH and subsequently enhancing hepatocyte serine production. Consequently, this metabolic cross-talk supports the…