1033-CSC-Driven Immune Evasion via Vesicle Signaling

Paper Talk · May 26, 2026 · 24m

This research identifies how cancer stem cells (CSCs) in triple-negative breast cancer orchestrate immune evasion through the secretion of extracellular vesicles (EVs). These vesicles carry the protein TSPAN8, which acts as a ligand that binds to CD103 receptors on T cells to trigger a specific metabolic signaling axis. This process drives the differentiation and expansion of immunosuppressive regulatory T cells (Tregs), creating a protected niche that facilitates tumor growth and metastasis. The study demonstrates that a positive feedback loop involving FOXP3 and CD103 sustains this…