326-mTOR Regulation of Cytoskeleton Drives Mitoxyperilysis

Paper Talk · Dec 19, 2025 · 13m

This article by Wang et al. introduces a novel lytic cell death pathway, termed mitoxyperilysis. This process is triggered by the simultaneous occurrence of innate immune activation and metabolic disruption (IIAMD), which together cause mitochondrial oxidative stress and damage. The core mechanistic step, which the authors name mitoxyperiosis, involves damaged mitochondria maintaining prolonged physical contact with the cell's plasma membrane, resulting in lethal local oxidative damage. This sustained contact and subsequent cell death are specifically regulated by the signaling complex…