389-TransBrain: Mapping Whole-Brain Between Humans and Mice

Paper Talk · Jan 11, 2026 · 17m

The paper details the development of TransBrain, a computational framework designed to bridge the gap between human and animal neuroscientific research. By integrating spatial transcriptomics, structural connectivity, and functional imaging, the tool enables the mapping of molecular and circuit-level data across species. Researchers used this platform to translate mouse optogenetic experiments into predicted human brain activation patterns, linking animal circuit manipulations to human cognitive maps. Furthermore, the study demonstrates TransBrain's clinical utility by aligning structural…