295-BRAIN-MAGNET Atlas of Non-Coding Regulatory Elements
The resource details the creation of a functional genomics atlas of over 148,000 regulatory regions in neural stem cells (NSCs) using ChIP-STARR-seq to understand gene regulation in neurodevelopment. Based on this atlas, the authors developed BRAIN-MAGNET, a convolutional neural network (CNN) that predicts non-coding regulatory element (NCRE) activity directly from DNA sequences. Critically, BRAIN-MAGNET is validated to prioritize functional non-coding variants linked to neurological diseases by identifying nucleotides essential for NCRE function, often outperforming existing variant…
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